Morrison Brett, Chaudhry Vinay
Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA.
Continuum (Minneap Minn). 2012 Feb;18(1):139-60. doi: 10.1212/01.CON.0000411565.49332.84.
Although medication, toxic, and vitamin-related neuropathies are rare causes of neuropathy, they are important to recognize because they are treatable and preventable. It is often difficult to conclusively demonstrate that a particular agent is the cause of neuropathy, but understanding the specific electrodiagnostic and clinical patterns produced by these agents is critical for making these assessments.
The clinical and electrodiagnostic features for many of these neuropathies have been well established. The exact mechanism by which some of these agents produce neuropathy is only now beginning to be revealed. These mechanisms are critical for both understanding the normal function of nerves as well as eventually devising specific treatments.
A large number of medications and toxins can produce neuropathy. This article reviews the clinical characteristics, electrodiagnostic features, and mechanism of action (when known) of those agents that produce the most severe, or perhaps the most unique features of, neuropathy.
尽管药物、中毒及维生素相关神经病是神经病的罕见病因，但因其可治疗且可预防，所以识别它们很重要。通常很难确凿证明某一特定药物是神经病的病因，但了解这些药物所产生的特定电诊断和临床模式对于进行这些评估至关重要。
许多此类神经病的临床和电诊断特征已得到充分确立。其中一些药物导致神经病的确切机制才刚刚开始被揭示。这些机制对于理解神经的正常功能以及最终设计出特定治疗方法都至关重要。
大量药物和毒素可导致神经病。本文综述了那些导致最严重或可能最独特神经病特征的药物的临床特征、电诊断特征及作用机制（已知时）。
