疱疹样皮炎的最新进展
Recent advances in dermatitis herpetiformis.
作者信息
Nakajima Kimiko
机构信息
Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Okocho, Nankoku, Kochi 783-8505, Japan.
出版信息
Clin Dev Immunol. 2012;2012:914162. doi: 10.1155/2012/914162. Epub 2012 Jul 2.
Abstract
Dermatitis herpetiformis is an autoimmune bullous disease that is associated with gluten sensitivity which typically presents as celiac disease. As both conditions are multifactorial disorders, it is not clear how specific pathogenetic mechanisms may lead to the dysregulation of immune responses in the skin and small bowel, respectively. Recent studies have demonstrated that IgA and antibodies against epidermal transglutaminase 3 play an important role in the pathogenesis of dermatitis herpetiformis. Here, we review recent immunopathological progress in understanding the pathogenesis of dermatitis herpetiformis.
摘要
疱疹样皮炎是一种自身免疫性大疱性疾病，与麸质敏感性相关，麸质敏感性通常表现为乳糜泻。由于这两种疾病都是多因素疾病，尚不清楚特定的致病机制如何分别导致皮肤和小肠免疫反应的失调。最近的研究表明，IgA和抗表皮转谷氨酰胺酶3抗体在疱疹样皮炎的发病机制中起重要作用。在此，我们综述了在理解疱疹样皮炎发病机制方面的最新免疫病理学进展。
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本文引用的文献
1
Dermatitis herpetiformis in China: a report of 22 cases.
J Eur Acad Dermatol Venereol. 2012 Jul;26(7):903-7. doi: 10.1111/j.1468-3083.2011.04204.x. Epub 2011 Oct 27.
2
Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.
Dermatol Clin. 2011 Jul;29(3):469-77, x. doi: 10.1016/j.det.2011.03.005.
3
Dermatitis herpetiformis. Part II. Diagnosis, management, and prognosis.
J Am Acad Dermatol. 2011 Jun;64(6):1027-33; quiz 1033-4. doi: 10.1016/j.jaad.2010.09.776.
4
Dermatitis herpetiformis. Part I. Epidemiology, pathogenesis, and clinical presentation.
J Am Acad Dermatol. 2011 Jun;64(6):1017-24; quiz 1025-6. doi: 10.1016/j.jaad.2010.09.777.
5
Dermatitis herpetiformis sera or goat anti-transglutaminase-3 transferred to human skin-grafted mice mimics dermatitis herpetiformis immunopathology.
J Immunol. 2011 Apr 1;186(7):4474-80. doi: 10.4049/jimmunol.1003273. Epub 2011 Feb 18.
6
Fibrillar IgA deposition in dermatitis herpetiformis--an underreported pattern with potential clinical significance.
J Cutan Pathol. 2010 Apr;37(4):475-7. doi: 10.1111/j.1600-0560.2009.01472.x. Epub 2009 Nov 16.
7
Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA/IgG serum antibodies to tissue transglutaminase.
J Pediatr Gastroenterol Nutr. 2010 Feb;50(2):140-6. doi: 10.1097/MPG.0b013e3181a81384.
8
IgA anti-epidermal transglutaminase antibodies in dermatitis herpetiformis and pediatric celiac disease.
J Invest Dermatol. 2009 Nov;129(11):2728-30. doi: 10.1038/jid.2009.142. Epub 2009 Jun 11.
9
Clinical, pathologic, and immunopathologic features of dermatitis herpetiformis: review of the Mayo Clinic experience.
Int J Dermatol. 2007 Sep;46(9):910-9. doi: 10.1111/j.1365-4632.2007.03214.x.
10
Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue.
J Invest Dermatol. 2008 Feb;128(2):332-5. doi: 10.1038/sj.jid.5701041. Epub 2007 Aug 30.
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