Papandreou Dimitrios, Karabouta Zaharoula, Rousso Israel
2nd Department of Pediatrics, School of Medicine and Ahepa General Hospital, Aristotle University of Thessaloniki, Street Kiriakidi 1, 54636 Thessaloniki, Greece.
Cholesterol. 2012;2012:572820. doi: 10.1155/2012/572820. Epub 2012 Jul 3.
Background. Nonalcoholic fatty liver disease (NAFLD) in children has been recognized as a major health burden. Serum lipids as well as dietary cholesterol (DC) intake may positively relate to development of NAFLD. The purpose of this study was to investigate anthropometric, biochemical, and dietary intake parameters of obese Greek children with and without NAFLD. Materials and Methods. Eighty-five obese children aged 8-15 (45 boys/40 girls) participated in the study. NAFLD was diagnosed by ultrasonography (US) in all subjects. Liver indexes were measured in all children. A 3-day dietary was recorded for all subjects. Results. 38 out of 85 children (44.7%) were found to have fatty liver. Obese children with increased levels of TC (95% CI: 1.721-3.191), low density lipoprotein (LDL) (95% CI: 1.829-3.058), and increased dietary cholesterol intakes (95% CI: 1.511-2.719) were 2.541, 2.612, and 2.041 times more likely to develop NAFLD compared with the children without NAFLD. Conclusion. The present study showed that TC, LDL, and DC were the strongest risk factors of development of NAFLD. Reducing body weight and dietary cholesterol intakes as well as decreasing serum TC and LDL levels are urgently necessary in order to prevent NAFLD and possible other health implications later in life.
背景。儿童非酒精性脂肪性肝病（NAFLD）已被视为一项重大的健康负担。血清脂质以及膳食胆固醇（DC）摄入量可能与NAFLD的发生呈正相关。本研究的目的是调查患有和未患有NAFLD的肥胖希腊儿童的人体测量学、生化和膳食摄入参数。材料与方法。85名8至15岁的肥胖儿童（45名男孩/40名女孩）参与了本研究。所有受试者均通过超声检查（US）诊断NAFLD。测量了所有儿童的肝脏指标。记录了所有受试者3天的饮食情况。结果。85名儿童中有38名（44.7%）被发现患有脂肪肝。与未患NAFLD的儿童相比，总胆固醇（TC）水平升高（95%置信区间：1.721 - 3.191）、低密度脂蛋白（LDL）水平升高（95%置信区间：1.829 - 3.058）以及膳食胆固醇摄入量增加（95%置信区间：1.511 - 2.719）的肥胖儿童发生NAFLD的可能性分别是其2.541倍、2.612倍和2.041倍。结论。本研究表明，TC、LDL和DC是NAFLD发生的最强风险因素。为预防NAFLD及日后可能出现的其他健康问题，迫切需要减轻体重、减少膳食胆固醇摄入量以及降低血清TC和LDL水平。
