使用一族I型错误概率消耗函数的序贯设计。
Group sequential designs using a family of type I error probability spending functions.
作者信息
Hwang I K, Shih W J, De Cani J S
机构信息
Biostatistics & Research Data Systems, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065-0914.
出版信息
Stat Med. 1990 Dec;9(12):1439-45. doi: 10.1002/sim.4780091207.
Performing planned or unplanned interim analyses on accumulating data in clinical trials is a frequent practice. In this paper, we propose a general one-parameter family of type I error probability spending functions to construct customized group sequential boundaries with unequal increments in information time. This proposed family generalized the spending functions of Lan and DeMets1 and Kim and DeMets.2 We give an example to illustrate the use of this family.
在临床试验中，对累积数据进行计划内或计划外的期中分析是一种常见做法。在本文中，我们提出了一个一般的单参数I型错误概率消耗函数族，以构建在信息时间上具有不等增量的定制组序贯边界。这个提出的函数族推广了Lan和DeMets1以及Kim和DeMets2的消耗函数。我们给出一个例子来说明这个函数族的使用。
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