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小鼠腭部及其对腭中缝扩展力的细胞反应。

The mouse palate and its cellular responses to midpalatal suture expansion forces.

机构信息

Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Orthod Craniofac Res. 2012 Aug;15(3):148-58. doi: 10.1111/j.1601-6343.2012.01547.x. Epub 2012 Jun 22.

DOI:10.1111/j.1601-6343.2012.01547.x
PMID:22812437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3812451/
Abstract

OBJECTIVES

To investigate the anatomy of the mouse palate, the midpalatal suture, and the cellular characteristics in the sutures before and immediately after midpalatal suture expansion.

MATERIALS AND METHODS

Wild-type C57BL/6 male mice, aged between 6 weeks and 12 months, were chosen for all the experiments. The complete palate of the non-operated group and the midpalatal suture-expanded group at different ages was used for histological, micro-CT, immunohistochemistry, and sutural cell analyses.

RESULTS

This study documents precise morphological and histological characteristics of the mouse palatal sutures. In addition to the opening of the midpalatal suture caused by expansion, both transverse and interpalatine sutures were also seen to be affected. Cellular density was decreased in different types of sutures following the application of mechanical force.

CONCLUSIONS

The detailed morphology and histology of the mouse palate and the cellular changes that occur following midpalatal suture expansion, as described here, will be helpful as a basis for further investigations of palatal suture tissue responses to mechanical force.

摘要

目的

研究小鼠腭部、正中腭缝及正中腭缝扩张前后的细胞特征。

材料与方法

本研究选用 6 周至 12 月龄的雄性 C57BL/6 野生型小鼠，所有实验均采用未手术组和不同年龄正中腭缝扩张组的完整腭部进行组织学、micro-CT、免疫组织化学和缝细胞分析。

结果

本研究记录了小鼠腭缝的精确形态和组织学特征。除了扩张引起的正中腭缝张开外，还观察到横向和腭间缝也受到影响。在机械力的作用下，不同类型的缝中的细胞密度降低。

结论

本文详细描述了小鼠腭部的形态和组织学以及正中腭缝扩张后发生的细胞变化，这将有助于进一步研究腭缝组织对机械力的反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf0/3812451/fd2979e2623c/nihms512089f7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf0/3812451/49866839f714/nihms512089f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf0/3812451/fd2979e2623c/nihms512089f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf0/3812451/86a246364ae3/nihms512089f1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf0/3812451/aff79b18d777/nihms512089f2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf0/3812451/e77cf9d3fc65/nihms512089f3.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf0/3812451/49866839f714/nihms512089f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf0/3812451/fd2979e2623c/nihms512089f7.jpg

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