Department of Medicine, Renal, Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA 19104, USA.
Curr Hypertens Rep. 2012 Oct;14(5):462-7. doi: 10.1007/s11906-012-0285-4.
Hypertension is the most common co-morbidity in chronic kidney disease (CKD) and the optimal target BP to prevent CKD progression has been hotly debated. Prior recommendations by various groups for BP targets for CKD in the range of less than 130/80 mm Hg have been based on the assumed benefits of lower BP in this population with exceedingly high risk for cardiovascular disease (CVD). Although there is suggestive data that lower BP may be helpful in patients with proteinuria and CKD, studies not directly link a treatment-related reduction in proteinuria to a benefit in kidney outcomes. There are ongoing studies which will provide more data on BP targets in CKD. Based on the currently available data we recommend a BP goal of less than 140/90 mm Hg in all patients with CKD.
高血压是慢性肾脏病（CKD）中最常见的合并症，预防 CKD 进展的最佳目标血压一直存在激烈的争论。先前不同组织针对 CKD 血压目标值的建议范围在 130/80mmHg 以下，这是基于心血管疾病（CVD）极高风险人群中降低血压的假定益处。尽管有数据提示蛋白尿和 CKD 患者的血压降低可能有益，但研究并未直接将治疗相关的蛋白尿减少与肾脏结局的获益联系起来。目前正在进行的研究将提供更多关于 CKD 血压目标值的数据。基于目前可用的数据，我们建议所有 CKD 患者的血压目标值应低于 140/90mmHg。
