Noizat-Pirenne F
Établissement français du sang Île-de-France, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
Transfus Clin Biol. 2012 Jun;19(3):132-8. doi: 10.1016/j.tracli.2012.03.004. Epub 2012 Jul 19.
Transfusion remains a key treatment in sickle cell disease. The occurrence of a delayed haemolytic transfusion reaction is not rare and is a life-threatening event. The main cause of delayed haemolytic transfusion reaction is production of alloantibodies against red blood cell antigens. The high rate of alloimmunization in sickle cell disease patients is mainly due to the differences of red blood groups between patients of African descent, and the frequently Caucasian donors. From an immuno-haematological point of view, delayed haemolytic transfusion reaction in sickle cell disease patients has specific features: classical antibodies known to be haemolytic can be encountered, but otherwise non significant antibodies, autoantibodies and antibodies related to partial and rare blood groups are also frequently found in individuals of African descent. In some cases, there are no detectable antibodies. As alloimmunization remains the main cause of delayed haemolytic transfusion reaction, it is extremely important to promote blood donation by individuals of African ancestry to make appropriate blood available.
输血仍然是镰状细胞病的关键治疗方法。迟发性溶血性输血反应并不罕见，且是危及生命的事件。迟发性溶血性输血反应的主要原因是针对红细胞抗原产生同种抗体。镰状细胞病患者同种免疫发生率高主要是由于非洲裔患者与通常为白种人的献血者之间血型存在差异。从免疫血液学角度来看，镰状细胞病患者的迟发性溶血性输血反应具有特定特征：可能会遇到已知具有溶血作用的经典抗体，但在非洲裔个体中也经常发现其他无明显意义的抗体、自身抗体以及与部分和罕见血型相关的抗体。在某些情况下，检测不到抗体。由于同种免疫仍然是迟发性溶血性输血反应的主要原因，促进非洲裔个体献血以提供合适的血液极其重要。
