Guasconi Lorena, Serradell Marianela C, Masih Diana T
Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), CONICET, Departamento de Bioquímica Clínica, Universidad Nacional de Córdoba, Medina Allende y Haya de la Torre, Ciudad Universitaria, Córdoba, Argentina.
Vet Immunol Immunopathol. 2012 Aug 15;148(3-4):359-63. doi: 10.1016/j.vetimm.2012.06.022. Epub 2012 Jul 4.
Immunomodulatory properties have been described for Fasciola hepatica excretory-secretory products (FhESP), with their interaction with the innate immune cells being crucial during the early stages of infection. Previously, we demonstrated that FhESP induce eosinophil apoptosis. In this work, the ability of FhESP to induce apoptosis of peritoneal macrophages was evaluated. These parasite products were observed to induce apoptosis in peritoneal macrophages stimulated in vitro with FhESP, as well as in cells recovered from infected mice. The ability of FhESP to modify the viability of macrophages by apoptosis induction may constitute a crucial event for extending its survival in the host.
肝片吸虫排泄-分泌产物（FhESP）具有免疫调节特性，其与天然免疫细胞的相互作用在感染早期至关重要。此前，我们证明FhESP可诱导嗜酸性粒细胞凋亡。在本研究中，评估了FhESP诱导腹膜巨噬细胞凋亡的能力。观察到这些寄生虫产物可诱导体外经FhESP刺激的腹膜巨噬细胞凋亡，以及从感染小鼠体内分离出的细胞凋亡。FhESP通过诱导凋亡来改变巨噬细胞活力的能力可能是其在宿主体内延长存活时间的关键事件。
