Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Curr Opin Cardiol. 2012 Sep;27(5):455-64. doi: 10.1097/HCO.0b013e328354d7b5.
Mitral valve disease is highly prevalent. Accurate characterization of normal anatomy and function of the mitral valve is crucial to understand the pathophysiology of mitral valve disease. This review summarizes recent advances in noninvasive cardiac imaging to assess normal mitral valve anatomy and function and provides an overview of the clinical applications of these novel imaging techniques in the evaluation of patients with mitral valve disease.
Echocardiography remains the first imaging technique for evaluation of the anatomy and function of the mitral valve. However, advances in minimally invasive and transcatheter valve repair/replacement procedures demand high spatial resolution images to accurately assess the anatomy of the mitral valve and its surrounding structures. Three-dimensional echocardiography improves two-dimensional echocardiography morphological and functional mitral valve evaluation. Furthermore, computed tomography provides high spatial resolution three-dimensional data and may constitute the modality of choice for additional morphological or geometrical study of the mitral valve and surrounding structures. In addition, cardiac magnetic resonance permits accurate assessment of anatomy and function of the mitral valve and is considered the method of reference to quantify mitral flow.
Any abnormality in any of the components of the mitral valve (annulus, leaflets, subvalvular apparatus, left ventricle and left atrium) may lead to mitral valve dysfunction. Current noninvasive cardiac imaging modalities permit accurate assessment of mitral valve anatomy and function. These imaging techniques refine our diagnostic performance, provide additional (patho)physiological insights and help to design new strategies for interventional or surgical treatment of the diseased mitral valve.
二尖瓣疾病的发病率很高。准确描述二尖瓣的正常解剖结构和功能对于理解二尖瓣疾病的病理生理学至关重要。本综述总结了评估正常二尖瓣解剖结构和功能的非侵入性心脏成像的最新进展,并概述了这些新技术在评估二尖瓣疾病患者中的临床应用。
超声心动图仍然是评估二尖瓣解剖结构和功能的首选影像学技术。然而,微创和经导管瓣膜修复/置换技术的进步需要高空间分辨率的图像来准确评估二尖瓣及其周围结构的解剖结构。三维超声心动图改善了二维超声心动图对二尖瓣形态和功能的评估。此外,计算机断层扫描提供了高空间分辨率的三维数据,并且可能构成二尖瓣及其周围结构的额外形态学或几何学研究的首选方式。此外,心脏磁共振可以准确评估二尖瓣的解剖结构和功能,被认为是定量二尖瓣血流的参考方法。
二尖瓣的任何一个组成部分(瓣环、瓣叶、瓣下装置、左心室和左心房)的任何异常都可能导致二尖瓣功能障碍。目前的非侵入性心脏成像技术可以准确评估二尖瓣的解剖结构和功能。这些成像技术提高了我们的诊断性能,提供了额外的(病理)生理学见解,并有助于设计新的策略来治疗病变的二尖瓣。