抑制癌症的嗜甜性：MnSOD 在调节瓦博格效应方面是否发挥作用？
Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect?
机构信息
Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA.
出版信息
Mitochondrion. 2013 May;13(3):170-88. doi: 10.1016/j.mito.2012.07.104. Epub 2012 Jul 20.
Abstract
Reactive oxygen species (ROS), while vital for normal cellular function, can have harmful effects on cells, leading to the development of diseases such as cancer. The Warburg effect, the shift from oxidative phosphorylation to glycolysis, even in the presence of adequate oxygen, is an important metabolic change that confers many growth and survival advantages to cancer cells. Reactive oxygen species are important regulators of the Warburg effect. The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. MnSOD is important in cancer development and progression. However, the significance of MnSOD in the regulation of the Warburg effect is just now being revealed, and it may significantly impact the treatment of cancer in the future.
摘要
活性氧（ROS）虽然对正常细胞功能至关重要，但也会对细胞产生有害影响，导致癌症等疾病的发生。即使在有足够氧气的情况下，从氧化磷酸化向糖酵解的转变——瓦堡效应，也是赋予癌细胞许多生长和存活优势的重要代谢变化。活性氧是瓦堡效应的重要调节因子。定位于线粒体的抗氧化酶锰超氧化物歧化酶（MnSOD）对于在富含氧气的环境中生存至关重要，因为它可以清除线粒体 ROS。MnSOD 在癌症的发生和发展中很重要。然而，MnSOD 在调节瓦堡效应中的意义刚刚被揭示出来，它可能会对未来癌症的治疗产生重大影响。
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