针对 PES1 以恢复乳腺癌中的 ERα/ERβ 比值。
Targeting PES1 for restoring the ERα/ERβ ratio in breast cancer.
出版信息
J Clin Invest. 2012 Aug;122(8):2771-3. doi: 10.1172/JCI65133. Epub 2012 Jul 23.
Abstract
Alteration of the ERα/ERβ balance is a critical step in breast cancer development and progression, and selective restoration of the activity of estrogen receptors has been proposed as one of the major therapeutic approaches for breast cancer. In this issue of JCI, Cheng et al. show that, by differentially modulating the stability of ERα and ERβ, PES1 increases the ERα/ERβ ratio and triggers breast tumor growth. These findings highlight PES1 as a potential target for the treatment of breast cancer.
摘要
雌激素受体（ER）α/β 平衡的改变是乳腺癌发生和发展的关键步骤，选择性恢复雌激素受体的活性已被提议作为乳腺癌的主要治疗方法之一。在本期 JCI 中，Cheng 等人表明，通过差异调节 ERα 和 ERβ 的稳定性，PES1 增加了 ERα/ERβ 比值并引发乳腺肿瘤生长。这些发现强调了 PES1 作为治疗乳腺癌的潜在靶点。
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1
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2
The different roles of ER subtypes in cancer biology and therapy.内质网亚型在癌症生物学和治疗中的不同作用。
Nat Rev Cancer. 2011 Jul 22;11(8):597-608. doi: 10.1038/nrc3093.
3
Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity.雌激素受体β通过下调 HER2/HER3 和上调 PTEN 抑制乳腺癌细胞中的 Akt 信号通路：对他莫昔芬敏感性的影响。
Breast Cancer Res. 2011 Apr 14;13(2):R43. doi: 10.1186/bcr2865.
4
ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.ERβ 通过使 HIF-1α 不稳定并抑制 VEGF 介导的 snail 核定位来阻碍前列腺癌 EMT：对 Gleason 分级的影响。
Cancer Cell. 2010 Apr 13;17(4):319-32. doi: 10.1016/j.ccr.2010.02.030.
5
Estrogen receptor-beta expression in invasive breast cancer in relation to molecular phenotype: results from the Nurses' Health Study.雌激素受体-β在浸润性乳腺癌中与分子表型的关系：来自护士健康研究的结果。
Mod Pathol. 2010 Feb;23(2):197-204. doi: 10.1038/modpathol.2009.158. Epub 2009 Nov 6.
6
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Cancer Sci. 2009 Dec;100(12):2255-60. doi: 10.1111/j.1349-7006.2009.01325.x. Epub 2009 Aug 25.
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9
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10
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Physiol Rev. 2007 Jul;87(3):905-31. doi: 10.1152/physrev.00026.2006.
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