Jafri M Saleet
School of Systems Biology, George Mason University, Manassas, VA, USA.
Methods Mol Biol. 2012;910:309-35. doi: 10.1007/978-1-61779-965-5_14.
Excitation-contraction coupling describes the processes relating to electrical excitation through force generation and contraction in the heart. It occurs at multiple levels from the whole heart, to single myocytes and down to the sarcomere. A central process that links electrical excitation to contraction is calcium mobilization. Computational models that are well grounded in experimental data have been an effective tool to understand the complex dynamics of the processes involved in excitation-contraction coupling. Presented here is a summary of some computational models that have added to the understanding of the cellular and subcellular mechanisms that control ventricular myocyte calcium dynamics. Models of cardiac ventricular myocytes that have given insight into termination of calcium release and interval-force relations are discussed in this manuscript. Computational modeling of calcium sparks, the elementary events in cardiac excitation-contraction coupling, has given insight into mechanism governing their dynamics and termination as well as their role in excitation-contraction coupling and is described herein.
兴奋-收缩偶联描述了与心脏中通过力的产生和收缩进行电兴奋相关的过程。它发生在从整个心脏到单个心肌细胞，再到肌节的多个层面。将电兴奋与收缩联系起来的一个核心过程是钙动员。基于实验数据的计算模型一直是理解兴奋-收缩偶联所涉及过程的复杂动力学的有效工具。本文总结了一些计算模型，这些模型增进了我们对控制心室肌细胞钙动力学的细胞和亚细胞机制的理解。本手稿讨论了对钙释放终止和间期-力关系有深入见解的心室肌细胞模型。钙火花是心脏兴奋-收缩偶联中的基本事件，对其动力学和终止机制以及在兴奋-收缩偶联中的作用的计算建模在本文中进行了描述。
