Department of Pathology, University Health Network, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, Canada.
J Mol Endocrinol. 2012 Aug 30;49(2):R69-78. doi: 10.1530/JME-12-0113. Print 2012 Oct.
Pituitary adenomas exhibit a wide range of behaviors. The prediction of aggressive or malignant behavior in pituitary adenomas remains challenging; however, the utility of biomarkers is rapidly evolving. In this review, we discuss potential biomarkers as they relate to aggressive behavior in pituitary adenomas. While detailed histological subtyping remains the best independent predictor of aggressive behavior in the majority of cases, evidence suggests that the additional analyses of FGFR4, MMP, PTTG, Ki-67, p53, and deletions in chromosome 11 may contribute to decisions concerning management of aggressive pituitary adenomas.
垂体腺瘤表现出广泛的行为。预测垂体腺瘤的侵袭性或恶性行为仍然具有挑战性；然而，生物标志物的应用正在迅速发展。在这篇综述中，我们讨论了与垂体腺瘤侵袭性行为相关的潜在生物标志物。虽然详细的组织学分型仍然是大多数情况下侵袭性行为的最佳独立预测因素，但有证据表明，对 FGFR4、MMP、PTTG、Ki-67、p53 和 11 号染色体缺失的进一步分析可能有助于决定侵袭性垂体腺瘤的治疗。
