Department of Pediatrics, University of Chieti, Italy.
Acta Paediatr. 2012 Sep;101(9):e416-21. doi: 10.1111/j.1651-2227.2012.02768.x.
To determine a possible relationship between migraine and body mass index.
Migraine shows a wide spectrum of comorbidities, including cardiocerebral, vascular, psychiatric, metabolic, neurological as well as other pathologies. Recent researches suggest that obesity was significantly correlated with migraine frequency and disability in children, as well as in adult population studies. We reviewed data from the literature to clarify this possible relationship.
Translational and basic science research shows multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding. Specifically, neurotransmittors such as serotonin, peptides such as orexin, and adipocytokines such as adiponectin and leptin have been suggested to have roles in both feeding and migraine. A relationship between migraine and body mass index exists, and therefore, interventions to modify body mass index may provide a useful treatment model for investigating whether modest weight loss reduces headache frequency and severity in obese migraineurs.
The effect of obesity and weight change on headache outcomes may have important implications for clinical care.
确定偏头痛与体重指数之间可能存在的关系。
偏头痛表现出广泛的合并症，包括心脑血管、血管、精神、代谢、神经以及其他病理学。最近的研究表明，肥胖与儿童偏头痛的频率和残疾以及成年人群的研究显著相关。我们回顾了文献中的数据，以阐明这种可能的关系。
转化和基础科学研究表明，偏头痛病理生理学和调节进食的中枢和外周途径之间存在多个重叠区域。具体而言，神经递质如血清素、肽如食欲素以及脂肪细胞因子如脂联素和瘦素被认为在进食和偏头痛中都有作用。偏头痛和体重指数之间存在关系，因此，改变体重指数的干预措施可能为研究适度减轻体重是否能减少肥胖偏头痛患者的头痛频率和严重程度提供有用的治疗模式。
肥胖和体重变化对头痛结果的影响可能对临床护理具有重要意义。
