Steffan Jean, Olivry Thierry, Forster Sophie L, Seewald Wolfgang
Novartis Animal Health, Schwarzwaldallee 214, Basel, Switzerland.
Vet Dermatol. 2012 Oct;23(5):410-e77. doi: 10.1111/j.1365-3164.2012.01071.x. Epub 2012 Jul 24.
Hypersensitivity (allergic) dermatitis (HD) is commonly seen in cats, causing pruritus and various patterns of skin lesions, including at least one of the following: head and neck excoriations, self-induced alopecia, eosinophilic plaques and miliary dermatitis. Few studies have evaluated the efficacy of therapeutic interventions for feline HD, and although various scales have been considered, none has been formally validated for the assessment of disease severity and its response to therapy.
To design and validate a novel scale (SCORing Feline Allergic Dermatitis; SCORFAD) to assess the value of different criteria used as outcome measures for the treatment of feline HD and to set minimal thresholds for defining the clinical success of tested interventions.
One hundred client-owned cats.
The SCORFAD scale was designed to include the four most frequently identified lesion types in feline HD (eosinophilic plaque, head and neck excoriations, self-induced alopecia and miliary dermatitis) across 10 body regions. The extent and severity of each lesion type were graded prior to inclusion and after 3 and 6 weeks in a clinical study to compare the efficacy of two doses of ciclosporin with placebo.
The SCORFAD scale was found to exhibit satisfactory content, construct, criterion and sensitivity to change. The percentage reduction in SCORFAD from baseline was determined to be the most valid assessment of clinical response. Inter- and intra-observer reliability was not assessed.
The SCORFAD scale is proposed for use as a validated tool for the assessment of disease severity and response to therapeutic interventions in clinical trials for feline HD.
超敏（过敏）性皮炎（HD）在猫中很常见，会引起瘙痒和各种皮肤病变模式，包括以下至少一种：头颈部擦伤、自我诱导脱毛、嗜酸性斑块和粟粒性皮炎。很少有研究评估治疗干预对猫HD的疗效，并且尽管考虑了各种评分标准，但没有一种经过正式验证可用于评估疾病严重程度及其对治疗的反应。
设计并验证一种新的评分标准（猫过敏性皮炎评分；SCORFAD），以评估用于治疗猫HD的不同标准作为结局指标的值，并设定定义测试干预临床成功的最低阈值。
100只客户拥有的猫。
SCORFAD评分标准旨在涵盖猫HD中四种最常见的病变类型（嗜酸性斑块、头颈部擦伤、自我诱导脱毛和粟粒性皮炎），分布在10个身体区域。在一项临床研究中，在纳入前以及3周和6周后对每种病变类型的范围和严重程度进行分级，以比较两种剂量的环孢素与安慰剂的疗效。
发现SCORFAD评分标准在内容、结构、标准和对变化的敏感性方面表现令人满意。从基线开始SCORFAD的降低百分比被确定为对临床反应最有效的评估。未评估观察者间和观察者内的可靠性。
建议将SCORFAD评分标准用作评估猫HD临床试验中疾病严重程度和对治疗干预反应的经过验证的工具。
