Szczepanik Marcin P, Wilkołek Piotr M, Adamek Łukasz R, Kalisz Grzegorz, Gołyński Marcin, Sitkowski Wiesław, Taszkun Iwona
Subdepartment of Clinical Diagnostics and Veterinary Dermatology (Szczepanik, Wilkołek, Adamek, Kalisz, Sitkowski, Taszkun) and Subdepartment of Internal Diseases of Farm Animals and Horses (Gołyński), Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Głęboka 30, 20-612 Lublin, Poland.
Can J Vet Res. 2018 Oct;82(4):306-311.
The aim of this study was to demonstrate whether there is a correlation between transepidermal water loss (TEWL) and the severity of skin lesions in cats with feline atopic dermatitis (AD). The severity of symptoms was determined by using 2 scoring systems for clinically assessing the skin lesions in cats: Scoring Feline Allergic Dermatitis (SCORFAD) and Feline Extent and Severity Index (FeDESI). Such a correlation between TEWL and systems for clinically evaluating symptoms has already been shown in humans and dogs. Measurements were taken in 18 European Shorthair cats: 11 females and 7 males. Scores were calculated using SCORFAD and FeDESI and TEWL was measured in 7 areas of the body. Correlations were calculated between SCORFAD and TEWL and between FeDESI and TEWL for each body region and the average TEWL was also calculated with each system. Positive correlations were found between SCORFAD and TEWL in 3 of the examined areas: thorax ( = 0.44, = 0.02); axilla ( = 0.39, = 0.04); and forelimb ( = 0.55, = 0.02). A correlation was also found between the average TEWL and SCORFAD ( = 0.41, = 0.03). In the case of FeDESI, a correlation was found in the forelimb ( = 0.53, = 0.02), but no correlation was found between FeDESI and the average TEWL. The results obtained showed that TEWL can be used as an additional tool in clinically assessing atopic dermatitis in cats, although it seems to be less useful in cats than in humans.
本研究的目的是证明猫过敏性皮炎（AD）猫的经表皮水分流失（TEWL）与皮肤病变严重程度之间是否存在相关性。症状的严重程度通过两种用于临床评估猫皮肤病变的评分系统来确定：猫过敏性皮炎评分（SCORFAD）和猫范围与严重程度指数（FeDESI）。TEWL与临床评估症状的系统之间的这种相关性已在人类和犬类中得到证实。对18只欧洲短毛猫进行了测量：11只雌性和7只雄性。使用SCORFAD和FeDESI计算分数，并在身体的7个部位测量TEWL。计算每个身体区域的SCORFAD与TEWL之间以及FeDESI与TEWL之间的相关性，并使用每个系统计算平均TEWL。在3个检查区域中发现SCORFAD与TEWL之间存在正相关：胸部（r = 0.44，p = 0.02）；腋窝（r = 0.39，p = 0.04）；和前肢（r = 0.55，p = 0.02）。平均TEWL与SCORFAD之间也发现了相关性（r = 0.41，p = 0.03）。在FeDESI的情况下，在前肢发现了相关性（r = 0.53，p = 0.02），但FeDESI与平均TEWL之间未发现相关性。获得的结果表明，TEWL可以用作临床评估猫过敏性皮炎的附加工具，尽管它在猫中的作用似乎比在人类中要小。
