Departamento de Biología Experimental, Universidad de Jaén, Edif. B-3, 23071 Jaén, Spain.
Mech Ageing Dev. 2012 Aug;133(8):563-74. doi: 10.1016/j.mad.2012.07.004. Epub 2012 Jul 21.
Extra virgin olive oil (EVOO) consumption has been traditionally related to a higher longevity in the human population. EVOO effects on health are often attributed to its unique mixture of phenolic compounds with tyrosol and hydroxityrosol being the most biologically active. Although these compounds have been extensively studied in terms of their antioxidant potential and its role in different pathologies, their actual connection with longevity remains unexplored. This study utilized the nematode Caenorhabditis elegans to investigate the possible effects of tyrosol in metazoan longevity. Significant lifespan extension was observed at one specific tyrosol concentration, which also induced a higher resistance to thermal and oxidative stress and delayed the appearance of a biomarker of ageing. We also report that, although tyrosol was efficiently taken up by these nematodes, it did not induce changes in development, body length or reproduction. In addition, lifespan experiments with several mutant strains revealed that components of the heat shock response (HSF-1) and the insulin pathway (DAF-2 and DAF-16) might be implicated in mediating tyrosol effects in lifespan, while caloric restriction and sirtuins do not seem to mediate its effects. Together, our results point to hormesis as a possible mechanism to explain the effects of tyrosol on longevity in C. elegans.
特级初榨橄榄油（EVOO）的消费传统上与人类的长寿有关。EVOO 对健康的影响通常归因于其酚类化合物的独特混合物，其中酪醇和羟基酪醇的生物活性最强。尽管这些化合物在抗氧化潜力及其在不同病理中的作用方面已经得到了广泛的研究，但它们与长寿的实际联系仍未得到探索。本研究利用秀丽隐杆线虫来研究酪醇对后生动物寿命的可能影响。在一个特定的酪醇浓度下观察到显著的寿命延长，这也诱导了更高的耐热性和抗氧化应激能力，并延迟了衰老生物标志物的出现。我们还报告说，尽管酪醇被这些线虫有效地吸收，但它不会引起发育、体长或繁殖的变化。此外，用几种突变株进行的寿命实验表明，热休克反应（HSF-1）和胰岛素途径（DAF-2 和 DAF-16）的成分可能参与介导酪醇对寿命的影响，而热量限制和 sirtuins 似乎不介导其影响。总之，我们的结果表明，应激反应可能是解释酪醇对秀丽隐杆线虫长寿影响的一种机制。
