Mo Jian-Hong, Liang Bo, Cen Jing-Tao, Li Wan-Ying, Mo Yong-An, Tang Ming-Cheng, Ye Dong, Long Qiu-Xia, Hu Xun, Zhai Yuan-Sheng
Department of Cardiology, the People's Hospital of Fengkai County, Zhaoqing, Guangdong, China.
Department of Cardiology, the First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, China.
Front Cardiovasc Med. 2025 Jul 15;12:1621655. doi: 10.3389/fcvm.2025.1621655. eCollection 2025.
Coronary slow flow (CSF), characterized by delayed coronary perfusion without significant coronary artery stenosis, remains a diagnostic challenge due to its elusive pathophysiology. This retrospective study aimed to evaluate the association between the thrombin-antithrombin (TAT) complex and CSF.
Ninety-one CSF patients and 74 subjects with normal coronary flow were recruited in this cohort. Coronary artery blood flow was quantified using the thrombolysis in myocardial infarction frame count (TFC) method. Plasma TAT complex levels were measured via chemiluminescent immunoassay. Logistic regression analyses and a receiver operating characteristic (ROC) curve were performed to determine the predictive value of TAT for CSF.
Compared with patients without CSF, patients with CSF showed higher plasma levels of TAT complex, total cholesterol, and low-density lipoprotein cholesterol, all of which were also positively correlated with TFC. However, multivariate logistic regression identified TAT as the only independent predictor of CSF after adjustment (OR: 1.71, 95% CI: 1.39-2.10, < 0.001). More specifically, ROC analysis revealed that a plasma TAT complex levels of 3.875 ng/ml predicted CSF with a specificity of 89.2% and a sensitivity of 62.6%.
Elevated plasma TAT complex levels are strongly associated with CSF and may serve as a candidate diagnostic biomarker.
冠状动脉血流缓慢（CSF）的特征是冠状动脉灌注延迟且无明显冠状动脉狭窄，由于其难以捉摸的病理生理学，仍然是一个诊断挑战。本回顾性研究旨在评估凝血酶 - 抗凝血酶（TAT）复合物与CSF之间的关联。
本队列招募了91例CSF患者和74例冠状动脉血流正常的受试者。使用心肌梗死溶栓帧数（TFC）方法对冠状动脉血流进行定量。通过化学发光免疫测定法测量血浆TAT复合物水平。进行逻辑回归分析和受试者工作特征（ROC）曲线分析以确定TAT对CSF的预测价值。
与无CSF的患者相比，CSF患者的血浆TAT复合物、总胆固醇和低密度脂蛋白胆固醇水平更高，所有这些指标也与TFC呈正相关。然而，多变量逻辑回归分析确定，调整后TAT是CSF的唯一独立预测因子（OR：1.71，95%CI：1.39 - 2.10，P < 0.001）。更具体地说，ROC分析显示，血浆TAT复合物水平为3.875 ng/ml时预测CSF的特异性为89.2%，敏感性为62.6%。
血浆TAT复合物水平升高与CSF密切相关，可能作为候选诊断生物标志物。
