Honer W G, Bassett A S, Kopala L, Kennedy J L
Department of Genetics, New York State Psychiatric Institute, New York.
Can J Psychiatry. 1990 Dec;35(9):776-83. doi: 10.1177/070674379003500910.
A research strategy which integrates known biological aspects of schizophrenia is proposed. The strategy includes genotype and phenotype components and emphasizes interactions. Its central feature is the comprehensive diagnostic assessment of patients with schizophrenia. Clinical and laboratory based methodologies are applied within the genotype and phenotype components of the strategy. Examples of research from each area and the potential interactions with other aspects of the strategy are presented. The expectation is that a greater understanding of the pathophysiology of schizophrenia will result from the application of the genotype-phenotype strategy and that consequently more efficacious treatments will ultimately be developed.
本文提出了一种整合精神分裂症已知生物学方面的研究策略。该策略包括基因型和表型成分，并强调相互作用。其核心特征是对精神分裂症患者进行全面的诊断评估。基于临床和实验室的方法应用于该策略的基因型和表型成分中。文中展示了每个领域的研究实例以及与该策略其他方面的潜在相互作用。期望通过应用基因型 - 表型策略能更深入地理解精神分裂症的病理生理学，并最终开发出更有效的治疗方法。
