Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública (CSISP), Avenida de Cataluña 21, 46020 Valencia, Spain.
Pediatr Infect Dis J. 2012 Dec;31(12):1300-2. doi: 10.1097/INF.0b013e318269e3ec.
To assess the effect that the rotavirus vaccine RotaTeq may have on the gut microbiota, this study searched for differences in intestinal bacterial composition between vaccinated and unvaccinated children. Bacterial diversity in fecal samples was evaluated by pyrosequencing of the 16S rRNA gene and taxonomic analyses using bioinformatics tools. No evidence of such differences was observed.
为了评估轮状病毒疫苗 RotaTeq 对肠道微生物群可能产生的影响,本研究旨在寻找接种和未接种疫苗儿童肠道细菌组成的差异。通过对 16S rRNA 基因进行焦磷酸测序和使用生物信息学工具进行分类分析来评估粪便样本中的细菌多样性。未观察到这种差异的证据。