钯介导的膦依赖的化学选择性双烯丙基烷基化反应生成螺环碳环化合物。
Palladium-mediated phosphine-dependent chemoselective bisallylic alkylation leading to spirocarbocycles.
机构信息
Equipe Chirosciences, UMR CNRS 7313-iSm2, Aix Marseille Université, Ecole Centrale de Marseille, Av Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France.
出版信息
Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8648-51. doi: 10.1002/anie.201204629. Epub 2012 Jul 24.
PMID:22829474
Abstract
Cycles everywhere: The selectivity in the transformations of 1,3-diones to carbocycles by palladium-catalyzed bisallylic alkylations is strongly dependent on the phosphine that is employed. Moreover, synthesized vinylcyclopentenes can be easily transformed into cycloheptadiene derivatives through a carbon-carbon allylic bond cleavage.
摘要
到处都是环
钯催化的双烯丙基烷基化反应将 1,3-二酮转化为碳环时的选择性强烈依赖于所使用的膦。此外，合成的乙烯基环戊烯可以很容易地通过碳-碳烯丙基键断裂转化为环庚二烯衍生物。
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