Dipietro Loretta, Yeckel Catherine W, Gribok Andrei
The John B. Pierce Laboratory, Yale School of Medicine, New Haven, CT 06519, USA.
J Aging Res. 2012;2012:803864. doi: 10.1155/2012/803864. Epub 2012 Jul 8.
We examined the relation between stress reactivity and 24 h glycemic control in 17 inactive, healthy older people (≥60 years) under both a novel psychophysical stress and a seated control condition. Plasma cortisol was measured over the course of the stress and recovery periods. Glycemic control was determined over the subsequent 3 h from an oral glucose tolerance test (OGTT) and over 24 h via continuous glucose monitoring (CGM). We observed significant (P < 0.05) elevations in perceived stress, cardiovascular activity, and peak cortisol response at 30 min (10.6 ± 3.1 versus 8.6 ± 2.6 μg·dL(-1), resp.) during the stress compared with the control condition; however, 3 h OGTT glucose and insulin responses were similar between conditions. The CGM data suggested a 30-40 min postchallenge delay in peak glucose response and attenuated glucose clearance over the 6 h following the stress condition, but these alterations were not statistically significant. Healthy older people may demonstrate minimal disruption in metabolic resiliency following everyday psychological stress.
我们在17名不活动的健康老年人（≥60岁）中，研究了在一种新型心理生理应激和静坐对照条件下，应激反应性与24小时血糖控制之间的关系。在应激和恢复期间测量血浆皮质醇。通过口服葡萄糖耐量试验（OGTT）在随后3小时内以及通过连续血糖监测（CGM）在24小时内测定血糖控制情况。与对照条件相比，我们观察到在应激期间，30分钟时感知应激、心血管活动和皮质醇峰值反应显著升高（分别为10.6±3.1与8.6±2.6μg·dL⁻¹）（P<0.05）；然而，两种条件下3小时OGTT的葡萄糖和胰岛素反应相似。CGM数据表明，应激条件后6小时内，葡萄糖峰值反应有30 - 40分钟的延迟，且葡萄糖清除减弱，但这些改变无统计学意义。健康老年人在日常心理应激后，代谢弹性可能仅有轻微破坏。
