Islam Tariqul, Rahman Ajijur, Islam Anwar Ul
Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.
ISRN Pharm. 2012;2012:472586. doi: 10.5402/2012/472586. Epub 2012 Jul 5.
To get better control in disease conditions, many people take herbs with conventional medicines, therefore, posing a risk of potential pharmacokinetic interactions between herbs and conventional drugs. The aqueous extract of the fresh leaves of Abroma augusta L. (Family: Sterculiaceae, Bengali name: Ulatkambal, English name: Devil's cotton, DC) is viscous and used traditionally to treat diabetes mellitus. This study was done to investigate the probable mechanism by which the aqueous extract of Abroma augusta L. is beneficial in managing type 2 DM and to observe the effects of this extract on absorption of metformin hydrochloride from the gastrointestinal tract. Studies were conducted in healthy Long Evans rats using Na-carboxymethyl cellulose (CMC) as positive control. Both Na-CMC and WSF of DC significantly (P < 0.05) reduced the absorption of glucose administered orally in fasted rats. On the other hand, WSF of DC significantly (P < 0.05) reduced the absorption of metformin hydrochloride in alloxan-induced diabetic rats. The results of this study suggest that WSF of DC may be beneficial in diabetic patients to improve glycemic control but should not be coadministered with metformin HCl for management of type 2 diabetes mellitus.
为了在疾病状态下更好地控制病情，许多人将草药与传统药物一起服用，因此，存在草药与传统药物之间潜在药代动力学相互作用的风险。昂天莲（锦葵科，孟加拉语名称：Ulatkambal，英文名：Devil's cotton，DC）鲜叶的水提取物具有粘性，传统上用于治疗糖尿病。本研究旨在探讨昂天莲水提取物对2型糖尿病有益的可能机制，并观察该提取物对盐酸二甲双胍胃肠道吸收的影响。以羧甲基纤维素钠（CMC）作为阳性对照，在健康的长爪沙鼠中进行研究。DC的Na-CMC和水悬浮液均显著（P<0.05）降低了禁食大鼠口服葡萄糖的吸收。另一方面，DC的水悬浮液显著（P<0.05）降低了四氧嘧啶诱导的糖尿病大鼠中盐酸二甲双胍的吸收。本研究结果表明，DC的水悬浮液可能对糖尿病患者改善血糖控制有益，但不应与盐酸二甲双胍联合用于2型糖尿病的治疗。
