结石性胆囊炎患者的幽门螺杆菌感染：一项基于医院的研究。

Helicobacter pylori infection in patients with calcular cholecystitis: a hospital based study.

作者信息

Abro Arshad Hussain, Haider Irfan Zafar, Ahmad Sarfraz

机构信息

Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.

出版信息

J Ayub Med Coll Abbottabad. 2011 Jan-Mar;23(1):30-3.

PMID:22830140

Abstract

BACKGROUND

Helicobacter pylori, a gram negative bacillus has been recognised as a public health problem and approximately half of the world population has H. pylori infection causes chronic gastritis, peptic ulcer disease and gastric malignancies. Objective of this study was to determine the frequency of H. pylori infection in patients of chronic calcular cholecystitis.

METHODS

This cross-sectional descriptive study was conducted at Liaquat University Hospital, Hyderabad, Pakistan from April 2010 to September 2010. All patients with history of gallstone presented with acute abdominal pain, dyspepsia, bloating and epigastric discomfort and diagnosed as calcular cholecystitis were further evaluated for the detection of H. pylori by serology and histopathology. Frequency and percentage of H. pylori infection in patients with calcular cholecystitis was calculated.

RESULT

Total 100 patients of cholelithiasis underwent laparoscopic cholecystectomy were recruited. The pain in upper right part of the abdomen was observed in all 100 patients, fever in 75%, nausea and vomiting in 68%, loss of appetite in 45%, feeling of tiredness or weakness in 22%, headache in 38%, chills in 52%, backache in 58%, pain under the right shoulder in 45%, heartburn in 67%, belching in 54%, indigestion in 80%, dyspepsia in 90%, bloating in 88%, and epigastric discomfort in 85% patients. Eighty-two percent patients had family history of gallstones. The mean age of overall study population was 48.72 +/- 8.78 years and mean age of H. pylori infected calcular cholecystitis patients was 47.98 +/- 5.43 years in male and 48.76 +/- 6.68 years in females. The H. pylori infection was identified in 55% patients with calcular cholecystitis, of which 32.7% were males and 67.3% were females (p=0.03, statistically significant). Majority of females (60%) had > or = 40 U/ml antibody titre (p=0.917, non-significant).

CONCLUSION

A possible relationship was identified between Helicobacter pylori and calcular cholecystitis.

摘要

背景

幽门螺杆菌，一种革兰氏阴性杆菌，已被公认为一个公共卫生问题，世界上约一半人口感染幽门螺杆菌，其可导致慢性胃炎、消化性溃疡病和胃部恶性肿瘤。本研究的目的是确定慢性结石性胆囊炎患者中幽门螺杆菌感染的频率。

方法

本横断面描述性研究于2010年4月至2010年9月在巴基斯坦海得拉巴的利亚卡特大学医院进行。所有有胆结石病史、出现急性腹痛、消化不良、腹胀和上腹部不适且被诊断为结石性胆囊炎的患者，通过血清学和组织病理学进一步评估幽门螺杆菌的检测情况。计算结石性胆囊炎患者中幽门螺杆菌感染的频率和百分比。

结果

总共招募了100例接受腹腔镜胆囊切除术的胆石症患者。所有100例患者均出现上腹部右侧疼痛，75%发热，68%恶心呕吐，45%食欲不振，22%感到疲倦或虚弱，38%头痛，52%寒战，58%背痛，45%右肩部下方疼痛，67%烧心，54%嗳气，80%消化不良，90%消化功能不良，88%腹胀，85%上腹部不适。82%的患者有胆结石家族史。整个研究人群的平均年龄为48.72±8.78岁，幽门螺杆菌感染的结石性胆囊炎男性患者平均年龄为47.98±5.43岁，女性患者平均年龄为48.76±6.68岁。55%的结石性胆囊炎患者被鉴定为幽门螺杆菌感染，其中男性占32.7%，女性占67.3%（p=0.03，具有统计学意义）。大多数女性（60%）抗体滴度≥40 U/ml（p=0.917，无统计学意义）。