Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS, Université Claude Bernard Lyon 1, Villeurbanne Cedex, France.
J Biomater Appl. 2013 Sep;28(3):385-94. doi: 10.1177/0885328212454315. Epub 2012 Jul 24.
Gadolinium-based nanoparticles are novel objects with interesting physical properties, allowing their use for diagnostic and therapeutic applications. Gadolinium-based nanoparticles were imaged following intravenous injection in healthy rats and rats grafted with 9L gliosarcoma tumors using magnetic resonance imaging and scintigraphic imaging. Quantitative biodistribution using gamma-counting of each sampled organ confirmed that these nanoparticles were rapidly cleared essentially by renal excretion. Accumulation of these nanoparticles in 9L gliosarcoma tumors implanted in the rat brain was quantitated. This passive and long-duration accumulation of gadolinium-based nanoparticles in tumor, which is related to disruption of the blood-brain barrier, is in good agreement with the use of these nanoparticles as radiosensitizers for brain tumors.
基于钆的纳米颗粒是具有有趣物理性质的新型物质，可用于诊断和治疗应用。静脉注射入健康大鼠和 9L 神经胶质肉瘤肿瘤移植大鼠后，使用磁共振成像和闪烁成像对基于钆的纳米颗粒进行成像。对每个取样器官进行伽马计数的定量生物分布证实，这些纳米颗粒主要通过肾脏排泄迅速清除。定量分析了这些纳米颗粒在大鼠脑内植入的 9L 神经胶质肉瘤肿瘤中的积累。这种基于钆的纳米颗粒在肿瘤中的被动和长时间积累与血脑屏障的破坏有关，这与将这些纳米颗粒用作脑肿瘤的放射增敏剂是一致的。
