Omlor G W, Lehner B, Wiedenhöfer B, Deininger C, Weber M A, Rehnitz C
Department Orthopädie, Unfallchirurgie und Paraplegiologie, Stiftung Orthopädische Universitätsklinik Heidelberg, Schlierbacher Landstr. 200a, 69118, Heidelberg, Deutschland.
Orthopade. 2012 Aug;41(8):618-22. doi: 10.1007/s00132-012-1907-x.
Osteoid osteoma was first described by Jaffe in 1935 as a benign bone neoplasm mainly located in the diaphyseal areas of long bones: 10% are located in the spine, mainly in the lumbar and thoracic posterior elements. Therapy is required due to nocturnal pain independent of the physical load and responds especially well to anti-inflammatory drugs due to the excessive production of prostaglandins in the nidus. Diagnosis is confirmed by multi-slice computed tomography (CT), magnetic resonance imaging (MRI) and skeletal scintigraphy scans. In cases with typical symptoms and imaging, open biopsies are rarely needed. Although CT-guided radiofrequency ablation is accepted as the gold standard treatment option for osteoid osteoma in the extremities, this technique is limited in spinal applications due to the risk of thermal damage to adjacent neurovascular structures. Technical advances in the administration of radiofrequency ablation have, however, resulted in new and expanded indications in the spine so that the necessity for open surgical excision of spinal osteoid osteoma is becoming less.
骨样骨瘤于1935年由贾菲首次描述,是一种主要位于长骨干骺端的良性骨肿瘤:10%位于脊柱,主要在腰椎和胸椎后部结构。由于夜间疼痛与体力负荷无关,因此需要治疗,并且由于瘤巢中前列腺素过度产生,对消炎药物反应特别良好。通过多层计算机断层扫描(CT)、磁共振成像(MRI)和骨闪烁扫描来确诊。在具有典型症状和影像学表现的病例中,很少需要进行开放活检。尽管CT引导下射频消融被公认为四肢骨样骨瘤的金标准治疗选择,但由于存在热损伤相邻神经血管结构的风险,该技术在脊柱应用中受到限制。然而,射频消融技术的进步导致了脊柱领域新的和扩大的适应症,以至于脊柱骨样骨瘤进行开放手术切除的必要性正变得越来越小。