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用于诊断缺铁性贫血的即时微流控装置。

Potential Point-of-Care Microfluidic Devices to Diagnose Iron Deficiency Anemia.

机构信息

Electronics and Communication Department, College of Engineering, Universiti Tenaga Nasional, KM-7 Jalan Uniten-Ikram, 43000 Kajang, Selangor, Malaysia.

Institute of Power Electronics (IPE), College of Engineering, Universiti Tenaga Nasional, KM-7 Jalan Uniten-Ikram, 43000 Kajang, Selangor, Malaysia.

出版信息

Sensors (Basel). 2018 Aug 10;18(8):2625. doi: 10.3390/s18082625.

Abstract

Over the past 20 years, rapid technological advancement in the field of microfluidics has produced a wide array of microfluidic point-of-care (POC) diagnostic devices for the healthcare industry. However, potential microfluidic applications in the field of nutrition, specifically to diagnose iron deficiency anemia (IDA) detection, remain scarce. Iron deficiency anemia is the most common form of anemia, which affects billions of people globally, especially the elderly, women, and children. This review comprehensively analyzes the current diagnosis technologies that address anemia-related IDA-POC microfluidic devices in the future. This review briefly highlights various microfluidics devices that have the potential to detect IDA and discusses some commercially available devices for blood plasma separation mechanisms. Reagent deposition and integration into microfluidic devices are also explored. Finally, we discuss the challenges of insights into potential portable microfluidic systems, especially for remote IDA detection.

摘要

在过去的 20 年中,微流控领域的快速技术进步为医疗保健行业生产了各种微流控即时诊断(POC)设备。然而,在营养领域,特别是在诊断缺铁性贫血(IDA)方面,潜在的微流控应用仍然很少。缺铁性贫血是最常见的贫血形式,影响着全球数十亿人,特别是老年人、妇女和儿童。本综述全面分析了未来针对与贫血相关的 IDA-POC 微流控设备的当前诊断技术。本综述简要介绍了各种具有检测 IDA 潜力的微流控设备,并讨论了一些用于血浆分离机制的商业上可用的设备。还探讨了试剂沉积和集成到微流控设备中的问题。最后,我们讨论了对潜在便携式微流控系统的见解的挑战,特别是针对远程 IDA 检测的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c811/6111990/8227e75842df/sensors-18-02625-g001.jpg

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