新型酰胺取代的三唑并吡咯并[2,1-c][1,4]苯并二氮杂卓（PBDT）衍生物的合成及细胞毒性测试。
Synthesis and cytotoxicity testing of new amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives.
机构信息
Medicinal Chemistry Laboratory, GVK Biosciences Private Limited, Plot No. 5C, IDA Uppal, Hyderabad 500039, AP, India.
出版信息
Molecules. 2012 Jul 25;17(8):8762-72. doi: 10.3390/molecules17088762.
Abstract
A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.
摘要
合成了一系列酰胺取代的三唑并吡咯并[2,1-c][1,4]苯并二氮杂卓（PBDT）衍生物，评估了它们对 MRC-5 和 Mahlavu 细胞系的细胞毒性。结果表明，具有间三氟甲基苯甲酰取代基的化合物 PBDT-7i 可以选择性地抑制 Mahlavu 细胞的生长，并且对 MRC-5 细胞的毒性较低。
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