National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Psychiatry Clin Neurosci. 2012 Aug;66(5):390-6. doi: 10.1111/j.1440-1819.2012.02374.x.
The aim of this study was to identify risk factors for suicide in Japanese substance use disorder (SUD) patients, adjusting for age and sex, and to examine sex differences in suicide risk among these patients.
A self-reporting questionnaire on age, sex, types of abused substances, current depression, and suicidality was administered to 1420 SUD patients who consecutively visited seven hospitals specializing in SUD treatment during the month of December 2009. Unadjusted/adjusted odds ratios of factors associated with suicidality were calculated for each sex.
The multivariate analysis using the total sample identified younger age, female sex, and current depression as risk factors for severe suicidality in SUD patients. The multivariate analysis by each sex demonstrated that younger age and current depression were associated with severe suicidality in male SUD patients. Only current depression was associated with severe suicidality in female patients.
Current depression is a risk factor for suicide in SUD patients common in both Western countries and Japan, although in Japanese SUD patients both younger age and female sex were more closely associated with severe suicidality than aspects of SUD. Additionally, young male SUD patients are speculated to have psychosocial features associated with suicidality in common with female SUD patients.
本研究旨在确定调整年龄和性别因素后日本物质使用障碍（SUD）患者自杀的风险因素，并探讨这些患者自杀风险的性别差异。
2009 年 12 月，1420 名 SUD 患者连续访问了 7 家专门治疗 SUD 的医院，他们填写了一份关于年龄、性别、滥用物质类型、当前抑郁和自杀意念的自我报告问卷。针对每个性别，计算了与自杀意念相关的因素的未调整/调整后的优势比。
使用总样本进行的多变量分析确定了年龄较小、女性和当前抑郁是 SUD 患者严重自杀意念的风险因素。按性别进行的多变量分析表明，年龄较小和当前抑郁与男性 SUD 患者的严重自杀意念相关。只有当前抑郁与女性患者的严重自杀意念相关。
目前的抑郁是 SUD 患者自杀的一个风险因素，这在西方国家和日本都很常见，尽管在日本的 SUD 患者中，年龄较小和女性性别与严重自杀意念的相关性比 SUD 方面更密切。此外，年轻的男性 SUD 患者可能具有与女性 SUD 患者共同的与自杀意念相关的社会心理特征。
