与发育相关的鼠类类圆线虫多不饱和脂肪酸组成分析

Analysis of polyunsaturated fatty acid composition of Strongyloides ratti in relation to development.

作者信息

Minematsu T, Yamazaki S, Uji Y, Okabe H, Korenaga M, Tada I

机构信息

Department of Parasitic Diseases, Kumamoto University Medical School, Japan.

出版信息

J Helminthol. 1990 Dec;64(4):303-9. doi: 10.1017/s0022149x00012347.

DOI:10.1017/s0022149x00012347

PMID:2283471

Abstract

The effect of linolenic acid (C18:3 omega 3) on the development of Strongyloides ratti first-stage larvae (L1) in culture was studied. The fatty acid composition of S. ratti free-living generations was analyzed by gas chromatography. L1 had abundant linoleic acid (C18:2 omega 6) but its proportion decreased with development. On the contrary, eicosapentaenoic acid (C20:5 omega 3) and C20:4 omega 3 were prominent in the filariform larva (L3). Because C20:5 omega 3 is generally synthesized from C18:3 omega 3 via C20:4 omega 3, the high ratio of C20:5 omega 3/C18:3 omega 3 of L3 in all the free-living generations suggested that polyunsaturated fatty acid metabolism, particularly the omega-3 series, and eicosanoids produced had important roles in the development of S. ratti L1.

摘要

研究了亚麻酸（C18:3 ω-3）对培养的鼠类圆线虫一期幼虫（L1）发育的影响。采用气相色谱法分析了鼠类圆线虫自由生活世代的脂肪酸组成。L1含有丰富的亚油酸（C18:2 ω-6），但其比例随着发育而降低。相反，二十碳五烯酸（C20:5 ω-3）和C20:4 ω-3在丝状幼虫（L3）中含量突出。由于C20:5 ω-3通常由C18:3 ω-3经C20:4 ω-3合成，所有自由生活世代中L3的C20:5 ω-3/C18:3 ω-3高比例表明，多不饱和脂肪酸代谢，尤其是ω-3系列，以及所产生的类花生酸在鼠类圆线虫L1的发育中具有重要作用。