Wang Tao, Nie Shuai, Reid Gavin E, Gasser Robin B
Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
Bio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Parkville, Victoria 3010, Australia.
Curr Res Parasitol Vector Borne Dis. 2021 Feb 24;1:100018. doi: 10.1016/j.crpvbd.2021.100018. eCollection 2021.
Lipidomics is a relatively recent molecular research field, and explores lipids (fats) and their biology using advanced mass spectrometry technologies. Although this field has expanded significantly in biomedical and biotechnological disciplines, it is still in its infancy in molecular parasitology. Our goal here is to review and discuss technical aspects of MS-based lipidomics and its recent applications to parasitic worms, as well as challenges and future directions for worm lipid research. In a multi-omic paradigm, we expect that the exploration of lipidomic data for parasitic worms will yield important insights into lipid-associated biological pathways and processes, including the regulation of essential signalling pathways, parasite invasion, establishment, adaptation and development.
脂质组学是一个相对较新的分子研究领域，它利用先进的质谱技术探索脂质（脂肪）及其生物学特性。尽管该领域在生物医学和生物技术学科中已得到显著扩展，但在分子寄生虫学领域仍处于起步阶段。我们在此的目标是回顾和讨论基于质谱的脂质组学的技术方面及其在寄生蠕虫中的最新应用，以及蠕虫脂质研究面临的挑战和未来方向。在多组学范式中，我们期望对寄生蠕虫脂质组数据的探索将为脂质相关的生物途径和过程带来重要见解，包括基本信号通路的调控、寄生虫的入侵、定植、适应和发育。
