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The 1-carbamoyl-2-oxo-4,5-dihydroxyimidazolidine component of ROS-induced DNA damage in white blood cells.ROS 诱导的白细胞 DNA 损伤中的 1-氨甲酰基-2-氧代-4,5-二羟基咪唑烷成分。
Radiat Res. 2010 Jul;174(1):101-6. doi: 10.1667/RR2087.1.
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Effects of antioxidant supplements on cancer prevention: meta-analysis of randomized controlled trials.抗氧化补充剂对癌症预防的影响：随机对照试验的荟萃分析。
Ann Oncol. 2010 Jan;21(1):166-79. doi: 10.1093/annonc/mdp286. Epub 2009 Jul 21.
3
A study of pyrimidine base damage in relation to oxidative stress and cancer.一项关于嘧啶碱基损伤与氧化应激和癌症关系的研究。
Br J Cancer. 2009 Aug 4;101(3):452-6. doi: 10.1038/sj.bjc.6605176. Epub 2009 Jul 14.
4
Formamidopyrimidines in DNA: mechanisms of formation, repair, and biological effects.DNA中的甲酰胺嘧啶：形成、修复及生物学效应机制
Free Radic Biol Med. 2008 Dec 15;45(12):1610-21. doi: 10.1016/j.freeradbiomed.2008.07.004. Epub 2008 Jul 17.
5
The nutritional prevention of cancer: 400 mcg per day selenium treatment.癌症的营养预防：每日400微克硒治疗。
Nutr Cancer. 2008;60(2):155-63. doi: 10.1080/01635580701684856.
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Associations of antioxidant nutrients and oxidative DNA damage in healthy African-American and White adults.健康非裔美国人和白人成年人中抗氧化营养素与氧化性DNA损伤的关联。
Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1428-36. doi: 10.1158/1055-9965.EPI-06-1030.
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Assessment of DNA damage at the dimer level: measurement of the formamide lesion.二聚体水平的DNA损伤评估：甲酰胺损伤的测量。
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Antioxidant vitamins and minerals in prevention of cancers: lessons from the SU.VI.MAX study.抗氧化维生素和矿物质在癌症预防中的作用：来自SU.VI.MAX研究的经验教训。
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Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells.氧化性DNA损伤的遗传效应：猴肾细胞中咪唑环开环的甲酰胺基嘧啶（Fapy损伤）和8-氧代嘌呤的比较诱变
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DNA 氧化损伤分析：抗氧化剂的作用。

Profiling oxidative DNA damage: effects of antioxidants.

机构信息

Departments of Cell Stress Biology, Dermatology and Cancer Prevention, Roswell Park Cancer Institute, Buffalo, NY, USA.

出版信息

Cancer Sci. 2012 Nov;103(11):2002-6. doi: 10.1111/j.1349-7006.2012.02391.x. Epub 2012 Sep 18.

DOI:10.1111/j.1349-7006.2012.02391.x
PMID:22834775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5439090/
Abstract

The goal of this research was to determine whether antioxidant usage could be correlated with changes in DNA damage levels. Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) was used to simultaneously measure five different oxidatively-induced base modifications in the DNA of WBC. Measurements of the five modifications were made before and after an 8-week trial during which participants took the SU.VI.MAX supplement. Levels of the five DNA modifications were compared among different groupings: users versus non-users of antioxidant supplements, before versus after the supplement intervention and men versus women. The statistical significance of differences between groups was most significant for pyrimidine base modifications and the observed trends reflect trends reported in epidemiological studies of antioxidant usage. A combination of modifications derived from pyrimidine bases is suggested as a superior indicator of oxidative stress.

摘要

本研究旨在确定抗氧化剂的使用是否与 DNA 损伤水平的变化相关。采用液相色谱-串联质谱法（LC-MS/MS）同时测量白细胞 DNA 中五种不同的氧化诱导碱基修饰。在为期 8 周的试验中，参与者服用 SU.VI.MAX 补充剂前后，分别测量了这五种修饰物。在不同的分组中比较了这五种 DNA 修饰物的水平：抗氧化补充剂的使用者与非使用者、补充剂干预前后以及男性与女性。组间差异的统计学意义在嘧啶碱基修饰物中最为显著，观察到的趋势反映了抗氧化剂使用的流行病学研究报告的趋势。来自嘧啶碱基的修饰物的组合被建议作为氧化应激的更好指标。