强直性肌营养不良的神经心理学缺陷
Neuropsychological deficits in myotonic muscular dystrophy.
作者信息
Malloy P, Mishra S K, Adler S H
机构信息
Butler Hospital, Providence, RI 02906.
出版信息
J Neurol Neurosurg Psychiatry. 1990 Nov;53(11):1011-3. doi: 10.1136/jnnp.53.11.1011.
Abstract
Twenty patients with myotonic muscular dystrophy (MMD) were compared with twenty controls on a battery of standardised neuropsychiological tests measuring motor and cognitive functions. The MMD patients performed significantly poorer on both motor and cognitive tests, particularly those assessing spatial functions. Although both motor and cognitive scores were correlated with age, significant diagnostic group by age interactions were present only for the motor measures. Therefore, while motor deficits in MMD may progress with ageing, cognitive deficits are mainly developmental and relatively stable.
摘要
对20例强直性肌营养不良（MMD）患者与20名对照者进行了一系列标准化神经心理学测试，以测量运动和认知功能。MMD患者在运动和认知测试中的表现均显著较差，尤其是在评估空间功能的测试中。虽然运动和认知分数均与年龄相关，但仅在运动测量中存在显著的诊断组与年龄交互作用。因此，虽然MMD的运动缺陷可能随年龄增长而进展，但认知缺陷主要是发育性的且相对稳定。
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