TGF-β 如何介导肾小管间质纤维化？
How does TGF-β mediate tubulointerstitial fibrosis?
机构信息
Department of Research, Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, TN, USA.
出版信息
Semin Nephrol. 2012 May;32(3):228-35. doi: 10.1016/j.semnephrol.2012.04.001.
Abstract
Tubulointerstitial fibrosis mediates the development of end-stage renal disease from renal injuries of all etiologies and is considered an important predictor of renal survival. Transforming growth factor-β (TGF-β) is one of the most important growth factors that promotes tubulointerstitial fibrosis, but the mechanisms whereby this occurs are not well defined. This is because TGF-β has pleiotropic effects that depend on the target cell type. This review discusses how TGF-β signaling in each of the relevant cell types (eg, tubular epithelium, fibroblasts) may contribute to tubulointerstitial fibrosis progression and suggests ways in which future research can improve our understanding of TGF-β-mediated tubulointerstitial fibrosis.
摘要
肾小管间质纤维化介导了各种病因引起的终末期肾病的发生，被认为是肾脏生存的一个重要预测因子。转化生长因子-β（TGF-β）是促进肾小管间质纤维化的最重要的生长因子之一，但具体机制尚不清楚。这是因为 TGF-β 具有依赖于靶细胞类型的多种效应。这篇综述讨论了 TGF-β 在每种相关细胞类型（例如，肾小管上皮细胞、成纤维细胞）中的信号转导如何促进肾小管间质纤维化的进展，并提出了未来研究可以改善我们对 TGF-β 介导的肾小管间质纤维化的理解的方法。
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