脉压升高独立预测 2 型糖尿病患者心房颤动的发生。
Increased pulse pressure independently predicts incident atrial fibrillation in patients with type 2 diabetes.
机构信息
Division of Internal Medicine, Sacro Cuore Hospital of Negrar, Verona, Italy.
出版信息
Diabetes Care. 2012 Nov;35(11):2337-9. doi: 10.2337/dc12-0314. Epub 2012 Jul 26.
Abstract
OBJECTIVE
To examine whether baseline pulse pressure (PP), a marker of arterial stiffness, is associated with subsequent development of atrial fibrillation (AF) in type 2 diabetes.
RESEARCH DESIGN AND METHODS
A total of 350 type 2 diabetic patients, who were free from AF at baseline, were followed for 10 years. A standard electrocardiogram was performed annually and a diagnosis of incident AF was confirmed in affected participants by a single cardiologist.
RESULTS
During the follow-up, 32 patients (9.1% of total) developed incident AF. After adjustments for age, sex, BMI, diabetes duration, presence of left ventricular hypertrophy, hypertension treatment, kidney dysfunction, and pre-existing history of coronary heart disease, heart failure, and mild valvular disease, baseline PP was associated with an increased incidence of AF (adjusted odds ratio 1.76 for each SD increment [95% CI 1.1-2.8]; P < 0.01).
CONCLUSIONS
Our findings suggest that increased PP independently predicts incident AF in patients with type 2 diabetes.
摘要
目的
探讨基线脉压（PP）作为动脉僵硬度的标志物，与 2 型糖尿病患者心房颤动（AF）的发生是否相关。
研究设计和方法
共纳入 350 例基线时无 AF 的 2 型糖尿病患者，随访 10 年。每年进行标准心电图检查，由一名心脏病专家对确诊的新发 AF 患者进行确诊。
结果
在随访期间，32 例患者（占总患者的 9.1%）发生了新发 AF。调整年龄、性别、BMI、糖尿病病程、左心室肥厚、高血压治疗、肾功能障碍以及既往冠心病、心力衰竭和轻度瓣膜病的病史后，基线 PP 与 AF 发生率的增加相关（每增加 1 个 SD 的调整比值比为 1.76[95%CI 1.1-2.8]；P<0.01）。
结论
我们的研究结果表明，基线 PP 升高独立预测 2 型糖尿病患者新发 AF。
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本文引用的文献
1
Atrial fibrillation.心房颤动。
Lancet. 2012 Feb 18;379(9816):648-61. doi: 10.1016/S0140-6736(11)61514-6. Epub 2011 Dec 11.
2
Mortality associated with atrial fibrillation in patients with myocardial infarction: a systematic review and meta-analysis.心肌梗死患者心房颤动相关死亡率：一项系统评价和荟萃分析。
Circulation. 2011 Apr 19;123(15):1587-93. doi: 10.1161/CIRCULATIONAHA.110.986661. Epub 2011 Apr 4.
3
Diagnosis and management of left ventricular diastolic dysfunction in the hypertensive patient.高血压患者左心室舒张功能障碍的诊断和治疗。
Am J Hypertens. 2011 May;24(5):507-17. doi: 10.1038/ajh.2010.235. Epub 2010 Dec 16.
4
Arterial wall structure and dynamics in type 2 diabetes mellitus methodological aspects and pathophysiological findings.2型糖尿病患者的动脉壁结构与动力学：方法学方面及病理生理学发现
Curr Diabetes Rev. 2010 Nov;6(6):367-77. doi: 10.2174/157339910793499146.
5
Validity of electrocardiographic classification of left ventricular hypertrophy across adult ethnic groups with echocardiography as a standard.
J Electrocardiol. 2008 Sep-Oct;41(5):404-12. doi: 10.1016/j.jelectrocard.2008.02.013. Epub 2008 May 2.
6
Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease.糖尿病与代谢综合征中的动脉僵硬度：心血管疾病的一条途径。
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7
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10
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