用于治疗和预防中风的临床神经保护药物。
Clinical neuroprotective drugs for treatment and prevention of stroke.
作者信息
Kikuchi Kiyoshi, Uchikado Hisaaki, Morioka Motohiro, Murai Yoshinaka, Tanaka Eiichiro
机构信息
Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Department of Neurosurgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
出版信息
Int J Mol Sci. 2012;13(6):7739-7761. doi: 10.3390/ijms13067739. Epub 2012 Jun 21.
Abstract
Stroke is an enormous public health problem with an imperative need for more effective therapies. In therapies for ischemic stroke, tissue plasminogen activators, antiplatelet agents and anticoagulants are used mainly for their antithrombotic effects. However, free radical scavengers, minocycline and growth factors have shown neuroprotective effects in the treatment of stroke, while antihypertensive drugs, lipid-lowering drugs and hypoglycemic drugs have shown beneficial effects for the prevention of stroke. In the present review, we evaluate the treatment and prevention of stroke in light of clinical studies and discuss new anti-stroke effects other than the main effects of drugs, focusing on optimal pharmacotherapy.
摘要
中风是一个巨大的公共卫生问题，迫切需要更有效的治疗方法。在缺血性中风的治疗中，组织纤溶酶原激活剂、抗血小板药物和抗凝剂主要因其抗血栓作用而被使用。然而，自由基清除剂、米诺环素和生长因子在中风治疗中已显示出神经保护作用，而抗高血压药物、降脂药物和降糖药物在预防中风方面已显示出有益效果。在本综述中，我们根据临床研究评估中风的治疗和预防，并讨论药物主要作用以外的新的抗中风作用，重点是优化药物治疗。
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