Grilo Reina A, López-Artíguez M, Castilla L, Castro M, García-Bragado F, Repetto M
Servicio de Medicina Interna. Hospital Universitario de Valme, Sevilla.
Med Clin (Barc). 1990 Sep 15;95(8):281-5.
To assess whether the wines from the south of Sevilla constitute a source of lead intoxication we have prospectively studied the blood levels of lead in 100 healthy controls, 100 patients with alcoholic and nonalcoholic hepatopathy and at the same time the lead content in 135 samples of water and in 176 samples of alcoholic drinks consumed by the above patients. The results demonstrate: 1) presence of normal amounts of lead (mean +/- SD = 62 +/- 5 micrograms/l) in 97 of wines analyzed; 2) a higher content of lead in wines from areas close to the highway A-4 (100 +/- 10 micrograms/l) than in those from more remote zones (42 +/- 3 micrograms/l, p less than 0.005); and 3) although the blood levels of lead in alcohol consumers are not at the toxic range (22.9 +/- 8.9 micrograms/l) are, however, significantly higher (p less than 0.0007) than in patients with no alcohol intake (16.8 +/- 9.9 micrograms/l) or in healthy persons (17.1 +/- 7.4 micrograms/l, p less than 0.0008). Blood levels of lead correlate with the condition of "usual drinker" but not with the amount of alcohol consumed, number of cigarettes, lead content of water and wine, nor with the existence of severe hepatopathy among the studied factors. Our results suggest that alcohol influences the lead metabolism and that the usual drinkers constitute a risk population for saturnism.
为评估塞维利亚南部的葡萄酒是否构成铅中毒的一个来源，我们前瞻性地研究了100名健康对照者、100名酒精性和非酒精性肝病患者的血铅水平，同时研究了上述患者饮用的135份水样和176份酒精饮料中的铅含量。结果表明：1）在所分析的97种葡萄酒中存在正常量的铅（平均±标准差=62±5微克/升）；2）靠近A-4高速公路地区的葡萄酒中铅含量（100±10微克/升）高于较远地区的葡萄酒（42±3微克/升，p<0.005）；3）尽管饮酒者的血铅水平未处于中毒范围（22.9±8.9微克/升），但显著高于不饮酒患者（16.8±9.9微克/升）或健康人（17.1±7.4微克/升，p<0.0008）。血铅水平与“经常饮酒者”的状况相关，但与饮酒量、吸烟数量、水和葡萄酒中的铅含量以及所研究因素中是否存在严重肝病无关。我们的结果表明，酒精影响铅代谢，经常饮酒者构成铅中毒的风险人群。
