School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Carbohydr Polym. 2012 Oct 1;90(2):1016-23. doi: 10.1016/j.carbpol.2012.06.036. Epub 2012 Jun 21.
This study investigates the use of a modified coaxial electrospinning process in the production of drug-loaded cellulose acetate (CA) nanofibers. With CA employed as a filament-forming matrix and ketoprofen (KET) as an active pharmaceutical ingredient, modified coaxial processes using sheath fluids comprising only mixed solvents were undertaken. With a sheath-to-core flow rate ratio of 0.2:1, the nanofibers prepared from the coaxial process had a smaller average diameter, narrower size distribution, more uniform structures, and smoother surface morphologies than those generated from single fluid electrospinning. In addition, the coaxial fibers provided a better zero-order drug release profile. The use of a sheath solvent means that the core jet is subjected to electrical drawing for a longer period, facilitating homogeneous core jet solidification and retarding the formation of wrinkles on the surface of the nanofibers. This modified coaxial electrospinning protocol allows the systematic fabrication of functional polymer nanofibers with improved quality.
本研究采用改良同轴静电纺丝工艺制备载药醋酸纤维素（CA）纳米纤维。以 CA 为纤维成型基质，酮洛芬（KET）为活性药物成分，采用仅含混合溶剂的鞘液进行改良同轴纺丝。在鞘液/芯液流速比为 0.2:1 时，与单流体静电纺丝相比，同轴纺丝制备的纳米纤维平均直径更小，粒径分布更窄，结构更均匀，表面形貌更光滑。此外，同轴纤维提供了更好的零级药物释放曲线。鞘液的使用意味着芯射流受到更长时间的电拉伸，有利于芯射流的均匀固化，并延缓纳米纤维表面皱纹的形成。这种改良的同轴静电纺丝方案可系统地制备具有改善质量的功能性聚合物纳米纤维。
