Microanalysis Laboratory, National Research Centre, Dokki, Giza, 12311, Egypt.
Talanta. 2012 Aug 15;97:96-102. doi: 10.1016/j.talanta.2012.04.001. Epub 2012 Apr 24.
A novel carbon paste electrode based on functionlized multi-walled carbon nanotubes/β-cyclodextrin composite (FMWCNTs/β-CD-CPE) is described for potentiometric determination of piroxicam (PXM). Improved sensitivity and selectivity was achieved by application of CDs as molecular host-guest recognition elements and MWCNTs. The electrochemical performance of carbon paste electrodes incroporated with FMWCNTs/β-CD composite was compared to those incroporated with MWCNTs and free CDs. Matrices compositions of each electrode are optimized on the basis of nature and content of the modifier, ionic sites and selected plasticizer. CPEs containing FMWCNTs/β-CD composite, hyamine (Hy) and 2-fluorophenyl 2-nitrophenyl ether (f-NPE) as electrode plasticizer, work satisfactory in the concentration range from 10(-6) to 10(-2) mol L(-1) with Nernstain compliance (58.7±0.9 mV decade(-1) activity) with fast response time of about 2s and exhibit adequate operational lifetime (16 weeks). The developed electrodes have been applied for the potentiometric determination of PXM in pharmaceutical formulation under batch and flow injection analysis (FIA). FIA allows the analysis of 120 samples h(-1) with the advantage of simplicity, accuracy and automation feasibility.
基于功能化多壁碳纳米管/β-环糊精复合材料（FMWCNTs/β-CD-CPE）的新型碳糊电极，用于吡罗昔康（PXM）的电位测定。通过应用 CD 作为分子主体 - 客体识别元件和 MWCNTs，提高了灵敏度和选择性。比较了掺入 FMWCNTs/β-CD 复合材料的碳糊电极与掺入 MWCNTs 和游离 CD 的碳糊电极的电化学性能。基于修饰剂的性质和含量、离子位和选择的增塑剂对每种电极的基质组成进行了优化。含有 FMWCNTs/β-CD 复合材料、Hyamine（Hy）和 2-氟苯基 2-硝基苯醚（f-NPE）作为电极增塑剂的 CPE 在 10（-6）至 10（-2）mol L（-1）浓度范围内工作良好，Nernstain 合规性（58.7±0.9 mV 十进制（-1）活性），响应时间快，约为 2s，具有足够的工作寿命（16 周）。该方法已用于药物制剂中 PXM 的批处理和流动注射分析（FIA）中的电位测定。FIA 具有简单、准确和自动化的优点，允许每小时分析 120 个样品。
