Microanalysis Laboratory, National Research Centre, Dokki, Giza, Egypt.
Talanta. 2011 Dec 15;87:40-5. doi: 10.1016/j.talanta.2011.09.037. Epub 2011 Oct 4.
The construction and performance characteristics of Biperiden (BP) polyvinyl chloride (PVC) electrodes are described. Different methods for electrode fabrication are tested including; incorporation of BP-ion pairs (BP-IPs), incorporation of ion pairing agents, or soaking the plain electrode in BP-ion pairs suspension solution. Electrode matrices were optimized referring to the effect of modifier content and nature, plasticizer and the method of modification. The proposed electrodes work satisfactorily in the BP concentration range from 10(-5) to 10(-2)mol L(-1), with fast response time (7s) and adequate operational lifetime (28 days). The electrode potential is pH independent within the range 2.0-7.0, with good selectivity towards BP in presence of various interfering species. The developed electrodes have been applied for potentiometric determination of BP in pharmaceutical formulation under batch and flow injection analysis (FIA) conditions. FIA offers the advantages of accuracy and automation feasibility with high sampling frequency. The dissolution profile for Akineton tablets (2mg BP/tablet) was studied using the proposed electrode in comparison with the official methods.
描述了比哌立登（BP）聚氯乙烯（PVC）电极的结构和性能特点。测试了不同的电极制备方法，包括：BP-离子对（BP-IPs）的掺入、离子对试剂的掺入或将普通电极浸泡在 BP-离子对悬浮液中。参照改性剂含量和性质、增塑剂以及改性方法的影响对电极基质进行了优化。所提出的电极在 BP 浓度范围为 10(-5) 到 10(-2)mol L(-1) 时工作良好，响应时间快（7s），工作寿命长（28 天）。电极电位在 2.0-7.0 范围内与 pH 无关，在存在各种干扰物质的情况下对 BP 具有良好的选择性。在批处理和流动注射分析（FIA）条件下，已将开发的电极用于药物制剂中 BP 的电位测定。FIA 具有高精度和自动化可行性的优点，并且可以进行高频率采样。使用所提出的电极与官方方法相比，研究了 Akineton 片剂（2mg BP/片）的溶出曲线。
