School of Social Work, University of Iowa, Iowa City, Iowa, USA.
J Pain Symptom Manage. 2013 Jan;45(1):43-55. doi: 10.1016/j.jpainsymman.2012.01.007. Epub 2012 Jul 26.
Timely and appropriate management of pain is essential to promote comfort at the end of life.
To determine if pain-related factors and nonpharmacologic interventions affect medication adherence in older cancer patients in community-based hospices.
The study involved cancer patients aged 55 years and older, newly admitted to one of the 13 community-based hospices in the midwestern U.S. A descriptive design with patients or their proxies providing information during two telephonic interviews and review of their hospice medical records were used.
A total sample of 65 patients was obtained, with data directly from 32 patients during Interview 1 (T(1)), 25 during Interview 2 (T(2)), and proxy reports for 33 (T(1)) and 30 (T(2)) patients. The overall mean pain medication adherence scores (maximum 9) for all patients were 8.43 (T(1)) and 8.38 (T(2)). For component analysis (three components; maximum of three points each), patients were the least adherent with opioid orders at both time points (2.65). Patients were the most adherent to nonsteroidal anti-inflammatory/acetaminophen orders at T(1) (2.91) and medications for neuropathic pain at T(2) (2.89). Data provided statistical evidence that patients with more hours of controlled pain in the past 24 hours were more likely to have had better adherence, whereas patients with higher levels of comfort over the last few days were more likely to have had worse adherence.
This study identified that pain medication adherence among older adults with cancer receiving hospice care is high. However, hospices must be alert to the fact that even as patients become more comfortable, adherence must continue to be emphasized to ensure that pain does not redevelop or exacerbate, if pain relief is a patient priority.
及时、适当的疼痛管理对于促进临终患者的舒适至关重要。
确定疼痛相关因素和非药物干预措施是否会影响社区临终关怀机构中老年癌症患者的药物依从性。
该研究纳入了年龄在 55 岁及以上、新入住美国中西部 13 家社区临终关怀机构之一的癌症患者。采用描述性设计,由患者或其代理人在两次电话访谈期间提供信息,并查阅他们的临终关怀医疗记录。
共获得 65 例患者的样本,其中 32 例患者在访谈 1(T1)时直接提供数据,25 例患者在访谈 2(T2)时提供数据,33 例患者的代理报告来自访谈 1(T1),30 例患者的代理报告来自访谈 2(T2)。所有患者的总体平均疼痛药物依从性评分(最高 9 分)分别为 T1 时的 8.43 分和 T2 时的 8.38 分。在(三个部分;每个部分最高 3 分)的成分分析中,患者在两个时间点对阿片类药物医嘱的依从性最低(2.65)。T1 时患者对非甾体抗炎药/对乙酰氨基酚医嘱的依从性最高(2.91),T2 时对治疗神经病理性疼痛药物的依从性最高(2.89)。数据提供了统计证据表明,过去 24 小时内疼痛得到更好控制的患者更有可能有更好的依从性,而过去几天舒适度更高的患者更有可能有较差的依从性。
本研究发现,接受临终关怀的老年癌症患者的疼痛药物依从性较高。然而,临终关怀机构必须意识到,即使患者的舒适度提高,也必须继续强调药物的依从性,以确保疼痛不会复发或加重,如果缓解疼痛是患者的首要任务。