Malin D H, Lake J R, Hammond M V, Fowler D E, Rogillio R B, Brown S L, Sims J L, Leecraft B M, Yang H Y
University of Houston-Clear Lake, TX 77058.
Peptides. 1990 Sep-Oct;11(5):969-72. doi: 10.1016/0196-9781(90)90018-z.
Yang et al. have isolated from bovine brain an octapeptide, FLFQPQRF-NH2 (F-8-F-NH2), with certain antiopiate properties. Malin et al. previously found that ICV injection of this peptide could precipitate an opiate abstinence syndrome in dependent rats. RIA revealed significantly higher levels of F-8-F-NH2 immunoreactivity in CSF withdrawn from the cisterna magna of morphine-dependent rats as opposed to CSF withdrawn from sham-implanted controls. ICV infusion of IgG from antiserum against F-8-F-NH2 significantly reduced the number of abstinence signs subsequently precipitated by naloxone in morphine-dependent rats.
杨等人已从牛脑中分离出一种八肽，即FLFQPQRF-NH2（F-8-F-NH2），具有一定的抗阿片样物质特性。马林等人先前发现，向脑室内注射这种肽可使依赖阿片类药物的大鼠出现阿片戒断综合征。放射免疫分析显示，与假植入对照组抽取的脑脊液相比，从吗啡依赖大鼠的小脑延髓池抽取的脑脊液中F-8-F-NH2免疫反应性水平显著更高。向脑室内注入抗F-8-F-NH2抗血清的IgG可显著减少随后纳洛酮诱发的吗啡依赖大鼠的戒断体征数量。
