Institute for Ecopreneurship, School of Life Sciences, University of Applied Sciences and Arts, Northwestern Switzerland, Muttenz, Switzerland.
N Biotechnol. 2012 Nov 15;30(1):88-95. doi: 10.1016/j.nbt.2012.07.008. Epub 2012 Jul 27.
Over the past seven years, we have been working with Sphingomonas sp. strain TTNP3, a bacterium capable of growing on numerous alkylphenolic compounds as a source of carbon and energy. We succeeded in elucidating an unusual pathway involving an attack at the quaternary alpha-carbon atom of the substrate, a position previously thought to be highly resistant to biodegradation. Combining analytical and bioanalytical methods, a good understanding of the reaction mechanisms, the enzymes catalysing them and the organization of the genes encoding them could be gained. First studies on the use of Sphingomonas sp. strain TTNP3 in wastewater treatment have been performed revealing promising results.
在过去的七年中，我们一直在研究能够以多种烷基酚化合物为碳源和能源生长的 Sphingomonas sp. strain TTNP3 细菌。我们成功阐明了一条不寻常的途径，涉及对底物的季碳原子的攻击，该位置以前被认为对生物降解具有高度抗性。通过结合分析和生物分析方法，可以很好地了解反应机制、催化它们的酶以及编码它们的基因的组织。已经对利用 Sphingomonas sp. strain TTNP3 进行废水处理进行了初步研究，结果表明前景广阔。
