Department of Molecular Biology, Institute of Biochemistry and Biology, University of Potsdam, Potsdam-Golm, Germany.
Cell Mol Life Sci. 2012 Oct;69(19):3245-57. doi: 10.1007/s00018-012-1092-4. Epub 2012 Jul 28.
The balance between cellular proliferation and differentiation is a key aspect of development in multicellular organisms. Recent studies on Arabidopsis roots revealed distinct roles for different reactive oxygen species (ROS) in these processes. Modulation of the balance between ROS in proliferating cells and elongating cells is controlled at least in part at the transcriptional level. The effect of ROS on proliferation and differentiation is not specific for plants but appears to be conserved between prokaryotic and eukaryotic life forms. The ways in which ROS is received and how it affects cellular functioning is discussed from an evolutionary point of view. The different redox-sensing mechanisms that evolved ultimately result in the activation of gene regulatory networks that control cellular fate and decision-making. This review highlights the potential common origin of ROS sensing, indicating that organisms evolved similar strategies for utilizing ROS during development, and discusses ROS as an ancient universal developmental regulator.
细胞增殖和分化之间的平衡是多细胞生物发育的一个关键方面。最近对拟南芥根的研究揭示了不同活性氧（ROS）在这些过程中的不同作用。在转录水平上至少部分控制着增殖细胞和伸长细胞中 ROS 之间平衡的调节。ROS 对增殖和分化的影响不仅在植物中具有特异性，而且似乎在原核和真核生命形式之间是保守的。从进化的角度讨论了 ROS 被接收的方式以及它如何影响细胞功能。最终进化出的不同氧化还原感应机制导致了控制细胞命运和决策的基因调控网络的激活。这篇综述强调了 ROS 感应的潜在共同起源，表明生物体在发育过程中利用 ROS 进化出了类似的策略，并讨论了 ROS 作为一种古老的通用发育调节剂。
