Dipartimento di Psicologia, Università di Bologna, Viale Berti Pichat 5, 40127 Bologna, Italy.
Soc Cogn Affect Neurosci. 2013 Feb;8(2):171-80. doi: 10.1093/scan/nss087. Epub 2012 Jul 25.
Disgust for contaminating objects (core disgust), immoral behaviors (moral disgust) and unsavory others (interpersonal disgust), have been assumed to be closely related. It is not clear, however, whether different forms of disgust are mediated by overlapping or specific neural substrates. We report that 10 patients with damage to the ventromedial prefrontal cortex (vmPFC) avoided behaviors that normally elicit interpersonal disgust (e.g. using the scarf of a busker) less frequently than healthy and brain-damaged controls, whereas they avoided core and moral disgust elicitors at normal rates. These results indicate that different forms of disgust are dissociated neurally. We propose that the vmPFC is causally (and selectively) involved in mediating interpersonal disgust, shaping patterns of social avoidance and approach.
对污染物体的厌恶（核心厌恶）、不道德的行为（道德厌恶）和令人不快的他人（人际厌恶），人们认为它们密切相关。然而，不同形式的厌恶是否由重叠或特定的神经基质介导尚不清楚。我们报告称，10 名腹内侧前额叶皮层（vmPFC）损伤的患者比健康和脑损伤对照者更频繁地避免通常会引起人际厌恶的行为（例如，使用街头艺人的围巾），而他们以正常的频率避免核心和道德厌恶的诱发物。这些结果表明，不同形式的厌恶在神经上是分离的。我们提出，vmPFC 是人际厌恶的因果（和选择性）中介，塑造了社交回避和接近的模式。
