Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Aging Clin Exp Res. 2012 Apr;24(2):134-8. doi: 10.1007/BF03325159.
Serum dehydroepiandrosterone- sulfate (DHEAS), the most abundant adrenal steroid hormone, may predict aging status and longevity in humans. The aims of this study are to clarify the fundamental properties of serum DHEAS as a biomarker for health in middle-aged men.
We investigated correlations of serum DHEAS with age or conventional health indices (body mass index, blood pressure, and 12 serum/blood tests) and associations of serum DHEAS with lifestyle factors (smoking, drinking, exercise, sleep) in 384 healthy men aged 30-49 years, randomly selected from voluntary attendees at a checkup.
Serum DHEAS had an inverse and stronger correlation with age (Spearman's r=-0.320, p<0.001) than with any conventional health indices used here. Regardless of age and BMI adjustments, serum DHEAS had a weak correlation with serum uric acid (crude Spearman's r=0.198, p<0.001), and its correlations with other conventional health indices were weaker or non-significant. Serum DHEAS rose in parallel with increased smoking and alcohol intake (p for trend <0.001 in both), but had no significant relationships with exercise or sleep.
Serum DHEAS reflects age better than health status evaluated by conventional health indices, and may increase with cigarette smoking and alcohol drinking in middle-aged healthy men.
硫酸脱氢表雄酮（DHEAS）是最丰富的肾上腺甾体激素，它可能预测人类的衰老状态和寿命。本研究的目的是阐明血清 DHEAS 作为中年男性健康生物标志物的基本特性。
我们调查了血清 DHEAS 与年龄或常规健康指数（体重指数、血压和 12 项血清/血液检查）的相关性，以及血清 DHEAS 与生活方式因素（吸烟、饮酒、运动、睡眠）的相关性，研究对象为随机选自体检自愿参加者的 384 名 30-49 岁健康男性。
血清 DHEAS 与年龄的相关性（Spearman r=-0.320，p<0.001）比与这里使用的任何常规健康指数的相关性更强，呈负相关。无论年龄和 BMI 调整如何，血清 DHEAS 与血尿酸呈弱相关（未经校正的 Spearman r=0.198，p<0.001），与其他常规健康指数的相关性较弱或无统计学意义。血清 DHEAS 随着吸烟和饮酒量的增加而升高（趋势检验 p<0.001），但与运动或睡眠无显著关系。
血清 DHEAS 比通过常规健康指数评估的健康状况更能反映年龄，并且在中年健康男性中可能随着吸烟和饮酒的增加而增加。
