Krorakai Karnpimon, Tontipattananon Siriporn, Leemahanil Rattikorn, Klangphukhiew Supannika, Wongrathanandha Chathaya, Phaibulpanich Akarin, Patramanon Rina
Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Department of Community Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pract Lab Med. 2021 Jan 18;24:e00204. doi: 10.1016/j.plabm.2021.e00204. eCollection 2021 Mar.
Dehydroepiandrosterone sulfate (DHEAs), a prohormone secreted by the adrenal gland, plays a role in the synthesis of sex hormones, namely, androgen and estrogen. It has been found that the amount of DHEAs is correlated with age, although most studies have focused on the correlation of serum DHEAs levels with age and sex. Thus, this noninvasive, cross-sectional study aimed to investigate the correlation of urine DHEAs levels with age and sex in healthy Thai volunteers aged 20-80 years.
DHEAs levels were measured in 178 healthy volunteers using electrochemiluminescence immunoassay and then normalized by creatinine. Multiple regression was performed to determine the correlation of urine DHEAs levels normalized by creatinine with age and sex.
The normalized DHEAs levels are correlated with age group for both sexes. Moreover, an increasing trend in DHEAs levels was found in the age group 20-29 years, and the DHEAs level peaked at the age group 30-39 years before declining with advancing age. Based on the multiple regression analyses, the significance of the interaction term ( < 0.05) indicates that both age and sex significantly contribute to the prediction of ln (DHEAs/Creatinine). Our fitted model implies the following: as age increases by 1 year, DHEAs/Creatinine is expected to decrease by 3.63% in females and by 2.18% in males.
This study reports more data on clinical reference value of urine DHEAs levels in healthy volunteers. Our result demonstrates urine DHEAs levels are associated with age and sex and decline by 2-3% a year.
硫酸脱氢表雄酮（DHEAs）是肾上腺分泌的一种激素原，在性激素（即雄激素和雌激素）的合成中发挥作用。已发现DHEAs的量与年龄相关，尽管大多数研究集中于血清DHEAs水平与年龄和性别的相关性。因此，这项非侵入性横断面研究旨在调查20 - 80岁健康泰国志愿者尿液DHEAs水平与年龄和性别的相关性。
使用电化学发光免疫分析法测量了178名健康志愿者的DHEAs水平，然后用肌酐进行标准化。进行多元回归以确定经肌酐标准化的尿液DHEAs水平与年龄和性别的相关性。
经标准化的DHEAs水平在两性中均与年龄组相关。此外，在20 - 29岁年龄组中发现DHEAs水平呈上升趋势，并且DHEAs水平在30 - 39岁年龄组达到峰值，之后随着年龄增长而下降。基于多元回归分析，交互项的显著性（<0.05）表明年龄和性别均对ln（DHEAs/肌酐）的预测有显著贡献。我们拟合的模型表明：年龄每增加1岁，女性的DHEAs/肌酐预计下降3.63%，男性下降2.18%。
本研究报告了更多关于健康志愿者尿液DHEAs水平临床参考值的数据。我们的结果表明尿液DHEAs水平与年龄和性别相关，且每年下降2 - 3%。
