Department of General Medicine, Juntendo University School of Medicine, Tokyo, Japan.
J Epidemiol Community Health. 2013 Feb;67(2):119-24. doi: 10.1136/jech-2011-200964. Epub 2012 Jul 29.
Cigarette smoking is a risk factor of coronary heart disease. Vascular calcification such as coronary artery calcium (CAC) and aortic calcium (AC) is associated with coronary heart disease. The authors hypothesised that cigarette smoking is associated with coronary artery and aortic calcifications in Japanese and Koreans with high smoking prevalence.
Random samples from populations of 313 Japanese and 302 Korean men aged 40-49 years were examined for calcification of the coronary artery and aorta using electron beam CT. CAC and AC were quantified using the Agatston score. The authors examined the associations of cigarette smoking with CAC and AC after adjusting for conventional risk factors and alcohol consumption. Current and past smokers were combined and categorised into two groups using median pack-years as a cut-off point in each of Japanese and Koreans. The never-smoker group was used as a reference for the multiple logistic regression analyses.
The ORs of CAC (score ≥10) for smokers with higher pack-years were 2.9 in Japanese (p<0.05) and 1.3 in Koreans (non-significant) compared with never-smokers. The ORs of AC (score ≥100) for smokers with higher pack-years were 10.4 in Japanese (p<0.05) and 3.6 in Koreans (p<0.05).
Cigarette smoking with higher pack-years is significantly associated with CAC and AC in Japanese men, while cigarette smoking with higher pack-years is significantly associated with AC but not significantly with CAC in Korean men.
吸烟是冠心病的一个危险因素。血管钙化，如冠状动脉钙（CAC）和主动脉钙（AC），与冠心病有关。作者假设，在吸烟率较高的日本人和韩国人中，吸烟与冠状动脉和主动脉钙化有关。
使用电子束 CT 对 313 名日本男性和 302 名 40-49 岁韩国男性的冠状动脉和主动脉钙化情况进行了随机抽样检查。使用 Agatston 评分法对 CAC 和 AC 进行量化。作者在调整了常规危险因素和饮酒量后，研究了吸烟与 CAC 和 AC 的相关性。将当前吸烟者和既往吸烟者合并，并以每个日本人烟龄中位数和每个韩国人烟龄中位数为截断点，将其分为两组。从不吸烟者组被用作多变量逻辑回归分析的参考组。
与从不吸烟者相比，较高烟龄的吸烟者 CAC（评分≥10）的 OR 为 2.9（p<0.05），韩国人为 1.3（非显著）。较高烟龄的吸烟者 AC（评分≥100）的 OR 为 10.4（p<0.05），韩国人为 3.6（p<0.05）。
在日本男性中，较高烟龄的吸烟与 CAC 和 AC 显著相关，而在韩国男性中，较高烟龄的吸烟与 AC 显著相关，但与 CAC 无显著相关性。
