Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 301 Boa Vista, 52050-080 Recife, PE, Brazil.
Evid Based Complement Alternat Med. 2012;2012:981352. doi: 10.1155/2012/981352. Epub 2012 Jul 12.
Background. Infantile colic is a distressing and common condition for which there is no proven standard treatment. Objective. To compare the efficacy of Mentha piperita with simethicone in treatment for infantile colic. Methods. A double-blind crossover study was performed with 30 infants attending IMIP, Recife, Brazil. They were randomized to use Mentha piperita or simethicone in the treatment of infantile colic during 7 days with each drug. Primary outcomes were mother_s opinion about responses to the treatment, number of daily episodes of colic, and time spent crying, measured by a chronometer. Mann-Whitney and chi-square tests were used to compare the results. This study was previously approved by the Ethical Committee in Research at IMIP. Results. At baseline daily episodes of infantile colic was 3.9 (±1.1) and the mean crying time per day was 192 minutes (±51.6). At the end of the study daily episodes of colic fell to 1.6 (±0.6) and the crying duration decreased to 111 (±28) minutes. All mothers reported decrease of frequency and duration of the episodes of infantile colic and there were no differences between responses to Mentha piperita and simethicone. Conclusions. These findings suggest that Mentha piperita may be used to help control infantile colic. However, these results must be repeated by others studies.
婴儿腹绞痛是一种痛苦且常见的病症，目前尚无经过验证的标准治疗方法。目的：比较胡椒薄荷与西甲硅油治疗婴儿腹绞痛的疗效。方法：巴西累西腓 IMIP 的 30 名婴儿参与了一项双盲交叉研究，他们被随机分配在 7 天的时间里使用胡椒薄荷或西甲硅油来治疗婴儿腹绞痛。主要结局是母亲对治疗反应的看法、每天绞痛发作次数以及使用秒表测量的哭泣时间。使用曼-惠特尼和卡方检验来比较结果。本研究先前已获得 IMIP 研究伦理委员会的批准。结果：基线时婴儿腹绞痛的每日发作次数为 3.9（±1.1），每日哭泣时间平均为 192 分钟（±51.6）。研究结束时，每日绞痛发作次数降至 1.6（±0.6），哭泣时间减少至 111（±28）分钟。所有母亲均报告说婴儿腹绞痛的发作频率和持续时间有所减少，而且胡椒薄荷和西甲硅油的反应没有差异。结论：这些发现表明胡椒薄荷可能有助于控制婴儿腹绞痛。然而，这些结果需要其他研究进一步证实。
