Hall Belinda, Chesters Janice, Robinson Anske
Department of Rural and Indigenous Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Moe, Victoria, Australia.
J Paediatr Child Health. 2012 Feb;48(2):128-37. doi: 10.1111/j.1440-1754.2011.02061.x. Epub 2011 Apr 7.
Infantile colic is a prevalent and distressing condition for which there is no proven standard therapy. The aim of this paper is to review medical and conventional treatments for infantile colic.
A systematic literature review was undertaken of studies on medical and conventional interventions for infantile colic from 1980 to March 2009. The results and methodological rigour of included studies were analysed using the CONSORT (Consolidated Standards Of Reporting Trials) 2001 statement checklist and Centre for Evidence Based Medicine critical appraisal tools.
Nineteen studies and two literature reviews were included for review. Pharmacological studies on Simethicone gave conflicting results and with Dicyclomine hydrochloride and Cimetropium bromide results were favourable but side effects were noted along with issues in study methodology. Some nutritional studies reported favourable results for the use of hydrolysed formulas in bottle-fed infants or low-allergen maternal diets in breastfed infants but not for the use of additional fibre or lactase. There were several issues in regards to methodological rigour. Behavioural studies on the use of increased stimulation gave unfavourable results, whereas results from the use of decreased stimulation and contingent music were favourable. These studies demonstrated poor methodological rigour.
There is some scientific evidence to support the use of a casein hydrolysate formula in formula-fed infants or a low-allergen maternal diet in breastfed infants with infantile colic. However, there is little scientific evidence to support the use of Simethicone, Dicyclomine hydrochloride, Cimetropium bromide, lactase, additional fibre or behavioural interventions. Further research of good methodological quality on low-allergenic formulas and maternal diets is indicated.
婴儿腹绞痛是一种常见且令人痛苦的病症，目前尚无经证实的标准疗法。本文旨在综述婴儿腹绞痛的医学及传统治疗方法。
对1980年至2009年3月期间关于婴儿腹绞痛医学及传统干预措施的研究进行系统的文献综述。使用CONSORT（试验报告统一标准）2001声明清单和循证医学中心的严格评价工具对纳入研究的结果和方法严谨性进行分析。
纳入19项研究和2篇文献综述进行评审。关于西甲硅油的药理学研究结果相互矛盾，而盐酸双环胺和溴甲阿托品的研究结果良好，但同时注意到有副作用以及研究方法方面的问题。一些营养研究报告称，在人工喂养婴儿中使用水解配方奶粉或在母乳喂养婴儿中采用低过敏原的母亲饮食有良好效果，但使用额外纤维或乳糖酶则不然。在方法严谨性方面存在若干问题。关于增加刺激使用的行为学研究结果不佳，而减少刺激和使用特定音乐的研究结果良好。这些研究显示出方法严谨性较差。
有一些科学证据支持在患有婴儿腹绞痛的人工喂养婴儿中使用酪蛋白水解配方奶粉或在母乳喂养婴儿中采用低过敏原的母亲饮食。然而，几乎没有科学证据支持使用西甲硅油、盐酸双环胺、溴甲阿托品、乳糖酶、额外纤维或行为干预措施。需要对低过敏配方奶粉和母亲饮食进行方法质量良好的进一步研究。
